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Antibacterial innovation in European SMEs

Nature Reviews Drug Discovery volume 15, pages 812–813 (2016)Cite this article

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There is a severe innovation gap in antibiotic R&D, and the field faces two daunting challenges. First, the discovery of novel antibiotics with no pre-existing cross- and co-resistance, and with a very low potential for emergence of resistance, presents considerable scientific obstacles, especially for Gram-negative bacteria. Second, large pharmaceutical companies, discouraged by years of unsuccessful discovery efforts and business model concerns, have mostly turned to other therapeutic areas.

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Figure 1: Landscape for European small and medium-sized enterprises in the antibacterial area.

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  1. Ursula Theuretzbacher is at the Center for Anti-Infective Agents, Eckpergasse 13, 1180 Vienna, Austria.,

    Ursula Theuretzbacher

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  1. Ursula Theuretzbacher
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Correspondence to Ursula Theuretzbacher.

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The author declares no competing financial interests.

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European SMEs* with antibacterial products in clinical trials (PDF 142 kb)

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Theuretzbacher, U. Antibacterial innovation in European SMEs. Nat Rev Drug Discov 15, 812–813 (2016). https://doi.org/10.1038/nrd.2016.229

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