Abstract
Technological advances coupled with novel collaborative strategies for compound sourcing and management are poised to transform the utility of high-throughput screening.
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References
Macarron, R. et al. Impact of high throughput screening in biomedical research. Nat. Rev. Drug. Discov. 10, 188–195 (2011).
Cook, D. et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat. Rev. Drug Discov. 13, 419–431 (2014).
Bakken, G. A. et al. Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy. J. Chem. Inf. Model. 52, 2937–2949 (2012).
Simpson, P. B. & Reichman, M. Opening the lead generation toolbox. Nat. Rev. Drug Discov. 13, 3–4 (2014).
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S.R, K.B. and G.P. are employees of AstraZeneca.
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Rees, S., Gribbon, P., Birmingham, K. et al. Towards a hit for every target. Nat Rev Drug Discov 15, 1–2 (2016). https://doi.org/10.1038/nrd.2015.19
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DOI: https://doi.org/10.1038/nrd.2015.19
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