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Drugs that lack single-agent activity: are they worth pursuing in combination?

Over the past decade, many anticancer drugs have been approved for use only in combination regimens and only in palliative settings, despite having negligible single-agent activity in the same disease. We examine whether these agents provide any tangible clinical benefits and are worthy of continued development, or whether R&D efforts would be better focused elsewhere.

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Correspondence to Vinay Prasad.

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The authors declare no competing financial interests.

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Approvals of drugs with limited evidence of single-agent activity as combination therapies (DOC 53 kb)

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Gyawali, B., Prasad, V. Drugs that lack single-agent activity: are they worth pursuing in combination?. Nat Rev Clin Oncol 14, 193–194 (2017).

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