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Bladder cancer

Multi-omic profiling refines the molecular view

Nature Reviews Clinical Oncology volume 15, pages 203–204 (2018)Cite this article

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Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease for which treatment has, historically, lagged behind that of other solid tumour types. A more detailed understanding of the biology of individual tumours, and the identification of molecular features providing prognostic and predictive information is key to the application of personalized care for patients with MIBC. The publication of a study of 412 samples now provides such data.

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Figure 1: mRNA expression-based subtypes of muscle-invasive bladder cancer according to The Cancer Genome Atlas.

References

  1. Torre, L. A. et al. Global cancer statistics, 2012. CA Cancer J. Clin. 65, 87–108 (2015).

    Article  Google Scholar 

  2. Abdollah, F. et al. Incidence, survival and mortality rates of stage-specific bladder cancer in United States: a trend analysis. Cancer Epidemiol. 37, 219–225 (2013).

    Article  Google Scholar 

  3. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507, 315–322 (2014).

  4. Robertson, A. G. et al. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell 171, 540–556.e25 (2017).

    Article  CAS  Google Scholar 

  5. Roberts, S. A. et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970–976 (2013).

    Article  CAS  Google Scholar 

  6. Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495–501 (2014).

    Article  CAS  Google Scholar 

  7. Rosenberg, J. E. et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387, 1909–1920 (2016).

    Article  CAS  Google Scholar 

  8. Choi, W. et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell 25, 152–165 (2014).

    Article  CAS  Google Scholar 

  9. Sjodahl, G. et al. Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classification. J. Pathol. 242, 113–125 (2017).

    Article  Google Scholar 

  10. Seiler, R. et al. Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy. Eur. Urol. 72, 544–554 (2017).

    Article  CAS  Google Scholar 

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Acknowledgements

Work in the authors' laboratory is supported by a programme grant from Yorkshire Cancer Research (LPA376).

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Authors and Affiliations

  1. Carolyn D. Hurst and Margaret A. Knowles are at the Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, University of Leeds, Leeds LS9 7TF, UK.,

    Carolyn D. Hurst & Margaret A. Knowles

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  1. Carolyn D. Hurst
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  2. Margaret A. Knowles
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Correspondence to Margaret A. Knowles.

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The authors declare no competing financial interests.

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Hurst, C., Knowles, M. Multi-omic profiling refines the molecular view. Nat Rev Clin Oncol 15, 203–204 (2018). https://doi.org/10.1038/nrclinonc.2017.195

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