2017 saw the publication of clinical trial data and the approval of new treatment approaches for metastatic urothelial carcinoma. Pembrolizumab is now a well-established treatment for patients with disease progression after cisplatin, with high-level evidence supporting its superiority over second-line chemotherapy. For patients ineligible for cisplatin, atezolizumab and pembrolizumab provide meaningful clinical benefit as frontline therapies.
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J.B. has been a consultant for Agensys, Amgen, Astra Zeneca, Bayer, Eisai, Genentech, Janssen, Merck, Novartis, Pfizer, Sanofi, and Seattle Genetics; has received financial support for research from Novartis and Sanofi, and royalties for his UpToDate contribution in urothelial tumours. R.N. declares no competing interests.
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Bellmunt, J., Nadal, R. Changes in expectations for metastatic urothelial carcinoma. Nat Rev Clin Oncol 15, 73–74 (2018). https://doi.org/10.1038/nrclinonc.2017.184
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