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Taking single-cell transcriptomics to the bedside

Nature Reviews Clinical Oncology volume 14, pages 590–592 (2017)Cite this article

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Important biological questions can be addressed by interrogating the transcriptomes of cancer cells. In a recently published landmark study, Giustacchini and collaborators used a single-cell approach to analyse mRNA of cancer cells derived from patients with chronic myeloid leukaemia. Herein, we discuss how this approach could be used to address relevant clinical questions.

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Acknowledgements

S.B. receives funding support from the St Baldrick's Foundation and the Wellcome Trust (WT107931/Z/15/Z). M.H. receives funding support from the Lister Institute of Preventive Medicine, the National Institute for Health Research and Newcastle-Biomedical Research Centre, and the Wellcome Trust (WT107931/Z/15/Z).

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Authors and Affiliations

  1. UK; and at the Department of Paediatrics, Sam Behjati is at the Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, University of Cambridge, Cambridge, Hills Road, CB2 0QQ, UK.,

    Sam Behjati

  2. and at the Department of Paediatrics, University of Cambridge, Cambridge, Hills Road, CB2 0QQ, UK.,

    Sam Behjati

  3. UK; and at the Department of Dermatology and Newcastle Biomedical Research Centre, Muzlifah Haniffa is at the Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, Newcastle Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE2 4LP, UK.,

    Muzlifah Haniffa

  4. and at the Department of Dermatology and Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE2 4LP, UK.,

    Muzlifah Haniffa

Authors
  1. Sam Behjati
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  2. Muzlifah Haniffa
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Corresponding authors

Correspondence to Sam Behjati or Muzlifah Haniffa.

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The authors declare no competing financial interests.

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Behjati, S., Haniffa, M. Taking single-cell transcriptomics to the bedside. Nat Rev Clin Oncol 14, 590–592 (2017). https://doi.org/10.1038/nrclinonc.2017.117

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