Health policy

Me-too drugs with limited benefits — the tale of regorafenib for HCC

An Erratum to this article was published on 28 November 2017

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Regorafenib is only the second agent approved by the FDA for the treatment of patients with advanced-stage hepatocellular carcinoma. Herein, we discuss the evidence that led to the approval of this agent. Examination of this process reveals important challenges associated with drug regulation, relating to trial design, treatment toxicity, and real-world clinical benefit.

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  • 28 November 2017

    In the illustration that accompanies this article, the structures of regorafenib and sorafenib were incorrectly drawn. In both structures, a double bond was omitted from the central phenyl ring so that it appeared as a 1,3-cyclohexadiene. The figure has been corrected in both the HTML and PDF versions of this News & Views.


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The work of V.P. is funded by the Laura and John Arnold Foundation to study low-value practices.

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Correspondence to Vinay Prasad.

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The authors declare no competing financial interests.

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Gyawali, B., Prasad, V. Me-too drugs with limited benefits — the tale of regorafenib for HCC. Nat Rev Clin Oncol 14, 653–654 (2017).

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