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Pancreatic cancer

Clinical practice guidelines — what is the evidence?

In three practice guidelines from ASCO, experts provide evidence-based recommendations that address overarching clinical questions for the management of patients with pancreatic cancer. These guidelines offer improved strategies for interdisciplinary patient management and highlight the need for further research in several areas.

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References

  1. Khorana, A. A. et al. Potentially curable pancreatic cancer: American Society of Clinical Oncology clinical practice guideline. J. Clin. Oncol. 34, 2541–2556 (2016).

    Article  Google Scholar 

  2. Balaban, E. P. et al. Locally advanced, unresectable pancreatic cancer: American Society of Clinical Oncology clinical practice guideline. J. Clin. Oncol. 34, 2654–2668 (2016).

    Article  Google Scholar 

  3. Sohal, D. P. et al. Metastatic pancreatic cancer: American Society of Clinical Oncology clinical practice guideline. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2016.67.1412 (2016).

  4. Bockhorn, M. et al. Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 155, 977–988 (2014).

    Article  Google Scholar 

  5. Chandrasegaram, M. D. et al. Meta-analysis of radical resection rates and margin assessment in pancreatic cancer. Br. J. Surg. 102, 1459–1472 (2015).

    Article  CAS  Google Scholar 

  6. Strobel, O. et al. Pancreatic cancer surgery: the new R-status counts. Ann. Surg. http://dx.doi.org/10.1097/SLA.0000000000001731 (2016).

  7. Neoptolemos, J. P. et al. Adjuvant chemotherapy with fluorouracil plus folinic acid versus gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304, 1073–1081 (2010).

    Article  CAS  Google Scholar 

  8. Neoptolemos, J. P. et al. ESPAC-4: a multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma. J. Clin. Oncol. Abstr. 34, aLBA4006 (2016).

    Article  Google Scholar 

  9. Strobel, O. et al. Pancreatic adenocarcinoma: number of positive nodes allows to distinguish several N categories. Ann. Surg. 261, 961–969 (2015).

    Article  Google Scholar 

  10. Allen, P. J. et al. Multi-institutional Validation Study of the American Joint Commission on Cancer (8th edition) changes for T and N staging in patients with pancreatic adenocarcinoma. Ann. Surg. http://dx.doi.org/10.1097/SLA.0000000000001763 (2016).

  11. Suker, M. et al. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol. 17, 801–810 (2016).

    Article  CAS  Google Scholar 

  12. Hackert, T. et al. Locally advanced pancreatic cancer: neoadjuvant therapy with FOLFIRINOX results in resectability in 60% of the patients. Ann. Surg. http://dx.doi.org/10.1097/SLA.0000000000001850 (2016).

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Correspondence to Markus W. Büchler.

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Strobel, O., Büchler, M. Clinical practice guidelines — what is the evidence?. Nat Rev Clin Oncol 13, 593–594 (2016). https://doi.org/10.1038/nrclinonc.2016.127

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