Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Risk factors

What do breast and CRC cancers and MS have in common?

Dairy cattle meat and milk factors are proposed as risks for colon and breast cancers. Several novel small circular DNAs that are genetically active in human cells have been isolated from bovine sera and milk. Such agents have also been detected in two lesions of multiple sclerosis. A unifying concept is presented putatively explaining the risks for these diseases that are associated with these factors.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Putative concept of multiple sclerosis pathogenesis.

References

  1. 1

    zur Hausen, H. Red meat consumption and cancer: reasons to suspect involvement of bovine infectious factors in colorectal cancer. Int. J. Cancer 130, 2475–2483 (2012).

    CAS  Article  Google Scholar 

  2. 2

    zur Hausen, H. & de Villiers, E.-M. Dairy cattle serum and milk factors contributing to the risk of colon and breast cancers. Int. J. Cancer 137, 959–967 (2015).

    CAS  Article  Google Scholar 

  3. 3

    Global Burden of Disease Cancer Collaboration. Global Burden of Cancer 2013. JAMA Oncol. 1, 505–527 (2015).

  4. 4

    Maytsetseg, B. & Riichiro, I. Changes and actual state of Mongolian meat market and distribution system: a case study of Ulaanbaatar City's “Khuchit Shonhor” food market. Presented at the International Association of Agricultural Economists Conference. http://purl.umn.edu/25528 (2006).

  5. 5

    Ji, J., Sundquist, J. & Sundquist, K. Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. Br. J. Cancer 112, 149–152 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Ascherio, A. Environmental factors in multiple sclerosis. Expert Rev. Neurother. 13 (12 Suppl.), 3–9 (2013).

    Article  Google Scholar 

  7. 7

    Whitley, C. et al. Novel replication-competent circular DNA molecules from healthy cattle serum and milk and multiple sclerosis-affected human brain tissue. Genome Announc. http://dx.doi.org/10.1128/genomeA.00849-14, (2014).

  8. 8

    Bauer, G., Götschl, M. & Höfler, P. Tumor-promoting activity of Epstein-Barr-virus-inducing factor transforming growth factor type beta (EIF/TGF-beta) is due to the induction of irreversible transformation. Int. J. Cancer 47, 881–888 (1991).

    CAS  Article  Google Scholar 

  9. 9

    Heilbronn, R., Bürkle, A., Stephan, S. & zur Hausen, H. The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification. J. Virol. 64, 3012–3018 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. 10

    Manuelidis, L. J. Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. J. Neurovirol. 17, 131–145 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Harald zur Hausen.

Ethics declarations

Competing interests

H.z.H. receives an unrestricted grant from ORYX, Munich.

PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

zur Hausen, H. What do breast and CRC cancers and MS have in common?. Nat Rev Clin Oncol 12, 569–570 (2015). https://doi.org/10.1038/nrclinonc.2015.154

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing