Haematopoeitic-cell transplantation from unrelated donors is associated with acute graft-versus-host disease (GVHD), and this risk is increased when donor and recipient are HLA-DPB1 mismatched. Researchers explored the possibility that GVHD risk is correlated with the rs9277534 allele and HLA-DPB1 mismatch in recipients. They genotyped 3,503 patients and showed that HLA-DPB1 expression was influenced by the rs9277534 marker: rs9277534G (high-expression allele) was associated with a greater GVHD risk in recipients than those with the rs9277534A (low-expression allele).
References
Petersdorf, E. W. et al. High HLA-DP expression and graft-versus-host disease. N. Engl. J. Med. 373, 599–609 (2015)
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Avoiding a mismatch to limit GVHD. Nat Rev Clin Oncol 12, 562 (2015). https://doi.org/10.1038/nrclinonc.2015.150
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DOI: https://doi.org/10.1038/nrclinonc.2015.150
