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Cervical cancer

Squamocolumnar junction ablation—tying up loose ends?

Despite the commercialization of HPV vaccines, cervical cancer remains a major cause of death, especially in developing countries. Recent data implicate a discrete population of cells within the cervical squamocolumnar junction in the pathogenesis of cervical precancerous lesions, indicating that ablation of these cells might reduce the rate of cervical cancer in high-risk populations.

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Figure 1: HPV-related cervical carcinogenesis.


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The authors thank Dr Frank McKeon, Wa Xian and their colleagues at the University of Liege and the Brigham and Women's Hospital for their helpful discussions. The work of the authors is supported in part by a grant from the National Cancer Institute (5R21CA173190-02 to C.P.C.), by the Belgian Fund for Medical Scientific Research (M.H.), by the Centre Anti-Cancereux près l'Université de Liège (M.H.) and by the Fonds Léon Frédéricq (M.H.).

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Correspondence to Michael Herfs.

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Herfs, M., Crum, C. Squamocolumnar junction ablation—tying up loose ends?. Nat Rev Clin Oncol 12, 378–380 (2015).

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