Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Surgery

Green light given for laparoscopic surgery for rectal cancer

Randomized trial data support the use of laparoscopic surgery for colon cancer; however, such evidence was lacking for rectal cancer. Now, the COLOR II randomized trial gives minimally invasive resection of rectal cancer the 'green light', answering the question 'should laparoscopic surgery be used?' The new key question is 'who should be performing laparoscopic surgery for rectal cancer?'

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lacy, A. M. et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 359, 2224–2229 (2002).

    Article  Google Scholar 

  2. Guillou, P. J. et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicenter, randomised controlled trial. Lancet 365, 1718–1726 (2005).

    Article  Google Scholar 

  3. Veldkamp, R. et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol. 6, 477–484 (2005).

    Article  Google Scholar 

  4. Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N. Engl. J. Med. 350, 2050–2059 (2004).

  5. Bonjer, H. J. et al. A randomized trial of laparoscopic versus open surgery for rectal cancer. N. Engl. J. Med. 372, 1324–1332 (2015).

    Article  CAS  Google Scholar 

  6. Kang, S. B. et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short term outcomes of an open-label randomized controlled trial. Lancet Oncol. 11, 637–645 (2010).

    Article  Google Scholar 

  7. Veenhof, A. A. et al. The surgical stress response and postoperative immune function after laparoscopic or conventional total mesorectal excision in rectal cancer: a randomized trial. Int. J. Colorectal Dis. 26, 53–59 (2011).

    Article  CAS  Google Scholar 

  8. Tekkis, P. P., Senagore, A. J., Delaney, C. P. & Fazio, V. W. Evaluation of the learning curve in laparoscopic colorectal surgery: comparison of right-sided and left-sided resections. Ann. Surg. 242, 83–91 (2005).

    Article  Google Scholar 

  9. Miskovic, D., Ni, M., Wyles, S. M., Tekkis, P. & Hanna, G. B. Learning curve and case selection in laparoscopic colorectal surgery: systematic review and international multicenter analysis of 4852 cases. Dis. Colon Rectum 55, 1300–1310 (2012).

    Article  Google Scholar 

  10. Dietz, D. W. Consortium for optimizing surgical treatment of rectal cancer (OSTRiCh). Multidisciplinary management of rectal cancer: the OSTRiCh. J. Gastrointest. Surg. 17, 1863–1868 (2013).

    Article  Google Scholar 

Download references

Acknowledgements

The author would like to acknowledge Dr Nadav Haim and Dr Isacco Montroni for their assistance with the preparation of this article for publication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven D. Wexner.

Ethics declarations

Competing interests

S.D.W. declares potential royalties for inventor's income from Covidien and Karl Storz. S.D.W. has also acted as a consultant for and received consulting fees from Karl Storz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wexner, S. Green light given for laparoscopic surgery for rectal cancer. Nat Rev Clin Oncol 12, 375–376 (2015). https://doi.org/10.1038/nrclinonc.2015.100

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrclinonc.2015.100

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer