Over the past decade, genetic testing for rare inherited mutations, such as BRCA1 and BRCA2 mutations, has been successfully incorporated into clinical practice. Next-generation sequencing of cancer-susceptibility genes and entire tumour genomes has transformed cancer care and prevention. The discoveries of new cancer syndromes have raised exciting opportunities and potential liabilities for cancer-care providers seeking to incorporate genomic approaches into preventive oncology practice.
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Acknowledgements
K.O. would like to acknowledge funding support from The Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative, and The Breast Cancer Research Foundation.
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Offit, K. A decade of discovery in cancer genomics. Nat Rev Clin Oncol 11, 632–634 (2014). https://doi.org/10.1038/nrclinonc.2014.170
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DOI: https://doi.org/10.1038/nrclinonc.2014.170
