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Decade in review—genomics

A decade of discovery in cancer genomics

Over the past decade, genetic testing for rare inherited mutations, such as BRCA1 and BRCA2 mutations, has been successfully incorporated into clinical practice. Next-generation sequencing of cancer-susceptibility genes and entire tumour genomes has transformed cancer care and prevention. The discoveries of new cancer syndromes have raised exciting opportunities and potential liabilities for cancer-care providers seeking to incorporate genomic approaches into preventive oncology practice.

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K.O. would like to acknowledge funding support from The Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative, and The Breast Cancer Research Foundation.

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Correspondence to Kenneth Offit.

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The author declares no competing financial interests.

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Offit, K. A decade of discovery in cancer genomics. Nat Rev Clin Oncol 11, 632–634 (2014).

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