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Decade in review—genomics

A decade of discovery in cancer genomics

Over the past decade, genetic testing for rare inherited mutations, such as BRCA1 and BRCA2 mutations, has been successfully incorporated into clinical practice. Next-generation sequencing of cancer-susceptibility genes and entire tumour genomes has transformed cancer care and prevention. The discoveries of new cancer syndromes have raised exciting opportunities and potential liabilities for cancer-care providers seeking to incorporate genomic approaches into preventive oncology practice.

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References

  1. 1

    Couch, F. J., Nathanson, K. L. & Offit, K. Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343, 1466–1470 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Domchek, S. M. et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 304, 967–975 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Easton, D. F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087–1093 (2007).

    CAS  Article  Google Scholar 

  4. 4

    Stadler, K., Schrader, K. A., Vijai, J., Robson, M. E. & Offit, K. Cancer genomics and inherited risk. J. Clin. Oncol. 32, 687–698 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Gaudet, M. M. et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 9, e1003173 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Walsh, T. et al. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc. Natl Acad. Sci. USA 108, 18032–18037 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Jones, S. et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324, 217 (2009).

    CAS  Article  Google Scholar 

  8. 8

    Testa, J. R. et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat. Genet. 43, 1022–1025 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Shah, S. et al. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat. Genet. 45, 1226–1231 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Bombard, Y., Robson, M. & Offit, K. Revealing the incidentalome when targeting the tumor genome. JAMA 310, 795–796 (2013).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

K.O. would like to acknowledge funding support from The Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative, and The Breast Cancer Research Foundation.

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Correspondence to Kenneth Offit.

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The author declares no competing financial interests.

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Offit, K. A decade of discovery in cancer genomics. Nat Rev Clin Oncol 11, 632–634 (2014). https://doi.org/10.1038/nrclinonc.2014.170

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