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Biological markers

Tailoring treatment and trials to prognosis

As we learn more about the biology of cancer, we may be able to apply prognostic biomarkers to select patients at high risk or low risk of disease recurrence or progression. This will allow a priori stratification of patients in clinical trials and will help to tailor treatment to patients.

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Figure 1: Molecular prognostic and pathology algorithm for colon cancer.

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Acknowledgements

The authors thank Ian Tomlinson, Nicholas B. La Thangue and Rachel Midgley for valuable scientific discussions while writing this manuscript.

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Correspondence to David J. Kerr.

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D. J. Kerr has received educational grants and speakers honorarium from Genomic Health and is a Director of Oxford Cancer Biomarkers. Y. Shi declares no competing interests.

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Kerr, D., Shi, Y. Tailoring treatment and trials to prognosis. Nat Rev Clin Oncol 10, 429–430 (2013). https://doi.org/10.1038/nrclinonc.2013.97

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