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Breast cancer in 2013

Genomics, drug approval, and optimal treatment duration

2013 saw much progress in breast cancer research. Advances in high-throughput technologies continue to refine our knowledge of the molecular biology of breast cancer, and are beginning to give insight into cancer evolution, drug resistance, and how to deploy precision therapeutics.

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References

  1. Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333–339 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Li, S. et al. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep. 4, 1116–1130 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Robinson, D. R. et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat. Genet. 45, 1446–1551 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Toy, W. et al. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat. Genet. 45, 1439–1445 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108–112 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. Dawson, S. J. et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N. Engl. J. Med. 368, 1199–1209 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Davies, C. et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet 381, 805–816 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Pivot, X. et al. 6 Months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial. Lancet Oncol. 14, 741–748 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Goldhirsch, A. et al. 2 Years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet 382, 1021–1028 (2013).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The work by the authors is supported in part by the National Cancer Institute of the NIH awards P30CA047904 (N. E. Davidson) and R01CA94118 (A. V. Lee). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors are also supported by funding through the Breast Cancer Research Foundation (N. E. Davidson and A. V. Lee), Susan G. Komen for the Cure (A. V. Lee), and the Pennsylvania Department of Health (N. E. Davidson and A. V. Lee). The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations, or conclusions.

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Correspondence to Nancy E. Davidson.

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Lee, A., Davidson, N. Genomics, drug approval, and optimal treatment duration. Nat Rev Clin Oncol 11, 71–72 (2014). https://doi.org/10.1038/nrclinonc.2013.250

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