Rearrangements of the ALK gene have been associated with sensitivity to crizotinib and other kinase inhibitors with activity against ALK. The phase III PROFILE 1007 randomized study of crizotinib versus chemotherapy has demonstrated that crizotinib is superior to standard second-line chemotherapy in ALK-positive non-small-cell lung cancer.
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The author has received research grants from Eli Lilly & Co., ImClone Systems and Pfizer, and advisory board and consulting fees from Boehringer Ingelheim and Pfizer.
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Doebele, R. Time to shift the burden of proof for oncogene-positive cancer?. Nat Rev Clin Oncol 10, 492–493 (2013). https://doi.org/10.1038/nrclinonc.2013.135