We read with great interest the Perspectives article by Funda Meric-Bernstam and Gordon Mills (Overcoming implementation challenges of personalized cancer therapy. Nat. Rev. Clin. Oncol. 9, 542–548; 2012),1 in which the authors mainly focused on the intrinsic characteristics of the tumour for the design of personalized therapy for patients with cancer. However, three important papers recently published in Nature2,3 and Nature Medicine4 clearly demonstrate that, in addition to cell-autonomous factors (that is, intrinsic tumour characteristics), non-cell-autonomous determinants (that is, the tumour microenvironment) contribute to drug resistance in cancer therapy.
Firstly, hepatocyte growth factor (HGF) secretion from stromal cells was shown to be responsible for resistance in molecular-targeted cancer therapy.2,3 Straussman et al.2 found that, in BRAF-mutant melanoma, high levels of HGF in the stroma was associated with poor response to BRAF inhibition, suggesting tumour microenvironment-mediated drug resistance. Moreover, Wilson et al.3 reported that the plasma HGF concentration was inversely related to the response to BRAF inhibition in patients with BRAF-mutant melanoma. Interestingly, HGF is not simply a prognostic biomarker because the combined inhibition of BRAF and the HGF–cMET axis (for example, using HGF-neutralizing antibodies or the MET-inhibitory small molecule crizotinib) can reverse drug resistance in BRAF-mutant melanoma.2
Secondly, Sun et al.4 identified Wnt-16b protein as a chemoexposed stroma-derived factor that is essential for resistance to chemotherapy. In prostate cancer, chemotherapy was shown to cause DNA damage in stromal cells, and WNT16B expression was subsequently induced by NF-κB after DNA damage. Secretion of Wnt-16b protein eventually reduced cancer-cell sensitivity to chemotherapy through non-cell-autonomous determinants contributed by the tumour microenvironment.
Along this line, patient-derived tumour xenografts (PDTX), characterized by the maintenance of the original tumour architecture, have recently emerged as a model for cancer drug development.5 Interestingly, as human stromal cells in PDTX models can be replaced by murine stromal cells with the sequential passage from animal to animal, this opens the possibility to develop models to study the specificity and mechanisms of drug resistance between mouse and human stromal cells.
Taken together, the current data indicate that accurate and efficient predictions of response to cancer treatment will be incomplete unless a combined and integral approach towards the elucidation of tumoural—and microenvironmental—heterogeneity is undertaken. Such an approach must also involve a special focus on the secreted stromal factors responsible for drug resistance in each tumour subtype.
Meric-Bernstam, F. & Mills, G. B. Overcoming implementation challenges of personalized cancer therapy. Nat. Rev. Clin. Oncol. 9, 542–548 (2012).
Straussman, R. et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487, 500–504 (2012).
Wilson, T. R. et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 487, 505–509 (2012).
Sun, Y. et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat. Med. 18, 1359–1368 (2012).
Tentler, J. J. et al. Patient-derived tumour xenografts as models for oncology drug development. Nat. Rev. Clin. Oncol. 9, 338–350 (2012).
The authors declare no competing financial interests.
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Masuda, S., Izpisua Belmonte, J. The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol 10, 79 (2013). https://doi.org/10.1038/nrclinonc.2012.127-c1
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