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Targeted therapies

Adjuvant bisphosphonates—an option with low estrogen?

The AZURE trial data add to the uncertainty of whether adjuvant bisphophonates are a valuable addition to the armamentarium in the treatment of early stage breast cancer. Although the overall trial results were negative, a prespecified subgroup analysis demonstrated a 25% reduction in the risk of relapse and death in postmenopausal patients.

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Figure 1: Hazard ratios of DFS in the AZURE postmenopausal subgroup and ABCSG-12 overall trial population.1,2


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M. Gnant has received research support from and has served as a consultant for AstraZeneca, Novartis, and Pfizer, and has received lecture fees and honoraria for participation on advisory boards from Amgen, AstraZeneca, Novartis, Pfizer, Roche, Sanofi-Aventis and Schering.

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Gnant, M. Adjuvant bisphosphonates—an option with low estrogen?. Nat Rev Clin Oncol 8, 698–699 (2011).

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