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Targeted therapies

Front-line therapy in lung cancer with mutations in EGFR

Nature Reviews Clinical Oncology volume 8, pages 571–573 (2011)Cite this article

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Large randomized phase III trials conducted in patients with non-small-cell lung cancer (NSCLC) harboring activating mutations in EGFR have demonstrated that erlotinib or gefitinib are superior to platinum-based chemotherapy. Zhou et al. have now confirmed that these agents represent the best treatment we can offer today as front-line therapy for EGFR-mutant NSCLC.boxed-text

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References

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  1. Istituto Toscano Tumori, Ospedale Civile, Viale Alfieri 36, Livorno, 57100, Italy

    Lorenza Landi & Federico Cappuzzo

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  1. Lorenza Landi
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  2. Federico Cappuzzo
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Correspondence to Federico Cappuzzo.

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Competing interests

F. Cappuzzo receives honoraria from AstraZeneca, Boehringer Ingelheim, Eli Lilly and Roche and he owns a patent on EGFR testing using fluorescence in situ hybridization. L. Landi declares no competing interests.

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Landi, L., Cappuzzo, F. Front-line therapy in lung cancer with mutations in EGFR. Nat Rev Clin Oncol 8, 571–573 (2011). https://doi.org/10.1038/nrclinonc.2011.135

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