Targeted therapies

Importance of patient selection for EGFR TKIs in lung cancer

Platinum-based chemotherapy has been the standard first-line treatment for patients with advanced non-small-cell lung cancer for decades. However, a recent study has shown the superiority of gefitinib treatment in comparison with chemotherapy in a molecularly selected cohort of patients harboring sensitizing EGFR mutations. These results demonstrate the importance of incorporating molecular selection into the design of lung cancer trials that use EGFR tyrosine kinase inhibitors.

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Correspondence to Giuseppe Giaccone.

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The authors declare no competing financial interests.

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Lopez-Chavez, A., Giaccone, G. Importance of patient selection for EGFR TKIs in lung cancer. Nat Rev Clin Oncol 7, 360–362 (2010).

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