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Failure of bevacizumab in early-stage colon cancer

A randomized phase III trial of patients with stage II and III colon cancer showed no benefit of adding bevacizumab to standard adjuvant oxaliplatin plus fluorouracil and leucovorin. Despite suggestive evidence of a short-term benefit, these data and other similar findings dictate that adjuvant bevacizumab should not be used in colon cancer.

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The author would like to thank Dr. Axel Grothey for helpful discussions.

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D. J. Sargent declares that he has previously acted as a consultant for Genentech.

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Sargent, D. Failure of bevacizumab in early-stage colon cancer. Nat Rev Clin Oncol 8, 10–11 (2011).

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