Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunotherapy

Can we include vaccines with stem-cell transplantation?

Nature Reviews Clinical Oncology volume 6, pages 503–505 (2009)Cite this article

Peptide vaccines to PRI, WT1, and BCR-ABL have shown promising results in early trials of patients with leukemia. We discuss vaccine strategies that have been developed against leukemia, and the potential of a vaccine and stem-cell transplant combination for the cure of patients with leukemia.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rezvani, K. et al. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 111, 236–242 (2008).

    Article  CAS  Google Scholar 

  2. Oka, Y. et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc. Natl Acad. Sci. USA 101, 13885–13890 (2004).

    Article  CAS  Google Scholar 

  3. Qazilbash, M. H. et al. PR1 Vaccine elicited immunological response after hematopoietic stem cell transplantation is associated with better clinical response and event-free survival. ASH Annual Meeting Abstracts 110, 577 (2007).

    Google Scholar 

  4. Bocchia, M. et al. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365, 657–662 (2005).

    Article  CAS  Google Scholar 

  5. Li, Z. et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin. Cancer Res. 11, 4460–4468 (2005).

    Article  CAS  Google Scholar 

  6. Rezvani, K. & Barrett, A. J. Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation. Best Pract. Res. Clin. Haematol. 21, 437–453 (2008).

    Article  CAS  Google Scholar 

  7. Rezvani, K. et al. Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem cell transplantation for acute lymphoblastic leukemia. Blood 110, 1924–1932 (2007).

    Article  CAS  Google Scholar 

  8. May, R. J. et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin. Cancer Res. 13, 4547–4555 (2007).

    Article  CAS  Google Scholar 

  9. Clave, E., Molldrem, J., Hensel, N., Raptis, A. & Barrett, A. J. Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia. J. Immunother. 22, 1–6 (1999).

    Article  CAS  Google Scholar 

  10. Mielke, S. et al. A clinical scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood 111, 4392–4402 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, MD, USA

    John Barrett

  2. Department of Hematology, Imperial College, London, UK

    Katayoun Rezvani

Authors
  1. John Barrett
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katayoun Rezvani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John Barrett.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barrett, J., Rezvani, K. Can we include vaccines with stem-cell transplantation?. Nat Rev Clin Oncol 6, 503–505 (2009). https://doi.org/10.1038/nrclinonc.2009.115

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrclinonc.2009.115

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing