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Targeted therapies

Cetuximab plus chemotherapy in patients with advanced NSCLC

Targeting EGFR in patients with non-small-cell lung cancer (NSCLC) in addition to chemotherapy might provide survival benefits in patients with EGFR-positive tumors. Indeed, results from the FLEX trial demonstrate that cetuximab in combination with platinum-based chemotherapy is a new treatment strategy for patients with advanced NSCLC.

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Figure 1: Schematic of EGFR signal transduction pathway.


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Corresponding author

Correspondence to David J. Kerr.

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Competing interests

Dr. David Kerr is on the Speakers bureau at Merk KGA. Dr. Rasul declares no competing interests.

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Rasul, K., Kerr, D. Cetuximab plus chemotherapy in patients with advanced NSCLC. Nat Rev Clin Oncol 6, 499–500 (2009).

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