The mode of transport you use to commute to work matters. A new study shows that cycling or walking to and from work reduces the risk of cardiovascular disease (CVD) incidence and death compared with nonactive commuting (using the car or public transport). Commuting by cycling also reduces the risk of cancer incidence and all-cause death. This prospective, population-based study included 263,450 participants recruited from 22 sites across the UK, with a median follow-up of 5 years for all-cause, CVD, and cancer mortality and 2.1 years for incident CVD and cancer. These associations had dose-response trends and were independent of confounding factors such as sex, age, residence in deprived regions, ethnicity, smoking status, recreational and occupational physical activity, sedentary behaviour, and dietary intake.