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Dyslipidaemia

The PCSK9 adventure — humanizing extreme LDL lowering

PCSK9 inhibitors are the most potent LDL-cholesterol lowering drugs on the market. The latest cardiovascular outcome trials of these anti-PCSK9 monoclonal antibodies show positive results with fully-human antibodies, although with modest effect on major adverse cardiovascular events in patients who attain LDL-cholesterol target levels with statin therapy, whereas humanized antibodies are associated with the development of neutralizing antibodies.

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Figure 1: Fully-human versus humanized therapeutic monoclonal antibodies.

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Acknowledgements

M.D.S. and S.F. were supported partially by NIH grant R01HL132985. The authors gratefully acknowledge Ms Deanna Plubell for assistance with the figure.

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Correspondence to Michael D. Shapiro or Sergio Fazio.

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M.D.S. received compensation for advisory activities from Alexion, Amgen, Bracco, and GE Healthcare. S.F. received compensation for advisory activities from Aegerion, Amarin, Amgen, Kowa, Merck, and Sanofi.

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Shapiro, M., Fazio, S. The PCSK9 adventure — humanizing extreme LDL lowering. Nat Rev Cardiol 14, 319–320 (2017). https://doi.org/10.1038/nrcardio.2017.66

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  • DOI: https://doi.org/10.1038/nrcardio.2017.66

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