Consensus Statement | Open | Published:

Expert consensus document

Echocardiography and lung ultrasonography for the assessment and management of acute heart failure

  •  & for the Acute Heart Failure Study Group of the European Society of Cardiology Acute Cardiovascular Care Association

Nature Reviews Cardiology volume 14, pages 427440 (2017) | Download Citation

Abstract

Echocardiography is increasingly recommended for the diagnosis and assessment of patients with severe cardiac disease, including acute heart failure. Although previously considered to be within the realm of cardiologists, the development of ultrasonography technology has led to the adoption of echocardiography by acute care clinicians across a range of specialties. Data from echocardiography and lung ultrasonography can be used to improve diagnostic accuracy, guide and monitor the response to interventions, and communicate important prognostic information in patients with acute heart failure. However, without the appropriate skills and a good understanding of ultrasonography, its wider application to the most acutely unwell patients can have substantial pitfalls. This Consensus Statement, prepared by the Acute Heart Failure Study Group of the ESC Acute Cardiovascular Care Association, reviews the existing and potential roles of echocardiography and lung ultrasonography in the assessment and management of patients with acute heart failure, highlighting the differences from established practice where relevant.

Key points

  • Over-reliance of traditional clinical findings and symptoms can potentially delay diagnosis of acute heart failure (AHF), prolonging the time to appropriate therapy

  • The use of echocardiography and lung ultrasonography can help to improve diagnostic accuracy and monitor responses to interventions in patients with AHF

  • Lung ultrasonography allows for rapid assessment of numerous conditions, including pulmonary oedema, pleural effusion, and pneumothorax

  • Use of echocardiography has extended beyond the traditional application in stable patients to become widespread in the acute and emergency settings

  • In the setting of AHF, echocardiography can be used to assess pericardial effusion, right ventricular dilatation, left ventricular systolic function, gross valvular abnormality, and potentially the presence of intracardiac masses

  • Echocardiography can also be used to monitor treatment in patients with cardiogenic shock

Main

Heart failure is the primary cause of hospital admission in >1 million patients per year in the USA, with 25% of patients being readmitted within 1 month, and 10–20% mortality at 6 months after discharge1,2. Acute heart failure (AHF) — either a new diagnosis in patients with no history of cardiac disease, or as a result of acute decompensation in patients with known heart failure — is the leading cause of hospital admission in individuals aged >65 years in the UK3. According to data from Europe, approximately 50% of these patients will be readmitted within 12 months, and 30% will be deceased at the 1-year follow-up4. Despite numerous clinical trials to assess optimal treatment and management strategies for patients with AHF, little improvement has been made in AHF outcomes in the past 30 years1,4,5, with management decisions largely based on expert consensus rather than robust evidence. The burden of AHF is therefore substantial, both to individual patients and to society6,7. The successful management of patients with any acute condition involves early diagnosis, the identification of underlying reversible causes, and the implementation of effective therapies in a timely manner, all while avoiding harm; all these factors are associated with better in-hospital and short-term prognosis8. This Consensus Statement, prepared by the Acute Heart Failure Study Group of the ESC Acute Cardiovascular Care Association, reviews the existing and potential roles of echocardiography and lung ultrasonography (LUS) in the assessment and management of patients with AHF.

AHF: a diagnostic and management challenge

AHF is a syndrome rather than a diagnosis per se, caused by a wide array of pathologies that result in a spectrum of disease severity ranging from breathlessness to cardiogenic shock or cardiac arrest. AHF is a highly lethal condition, and studies have shown that minimizing the 'time to appropriate therapy' — the initiation of treatment as soon as possible, including in the prehospital setting — is potentially beneficial in improving outcomes9,10. AHF is variably defined as the rapid onset or acute worsening of symptoms and signs of heart failure that is associated with elevated plasma levels of natriuretic peptides4,11. However, substantial diagnostic uncertainty is inevitable when relying only on traditional clinical findings, and currently a lack of specificity exists in routine investigations for this condition. Indeed, although patients often present with a suggestive history, clinical features (such as shock, and pulmonary or peripheral congestion), and/or symptoms related to the underlying potential cause, these traditional clinical features are frequently absent; over-reliance on these factors might delay diagnosis and implementation of appropriate therapy, or contribute to a missed diagnosis in up to 20% of patients12,13. Furthermore, patients' clinical features might vary according to the site of initial medical contact and the management strategies employed14,15.

The majority of patients with AHF present to emergency departments; however, many patient are also assessed and managed in other acute care settings such as in intensive care and inpatient cardiology units. Patients with AHF usually present with symptoms of congestion and breathlessness rather than cardiac arrest or shock16. Symptoms of breathlessness account for 3–5% of emergency department attendances in Europe and the USA, and the major causes of breathlessness and their prevalence include AHF (50%), pneumonia or bronchitis (20%), exacerbation of chronic obstructive pulmonary disease or asthma (20%), and pulmonary embolism (5–10%)16,17. Current guidelines recommend that clinical examination and investigations should be integrated to form the diagnosis, including the use of electrocardiogram (ECG), chest radiograph, and biomarkers such as natriuretic peptides, troponin, and D-dimer as indicated16,18,19. Unfortunately, these data can be challenging to interpret, in particular in the 10–15% of patients in whom two concomitant diagnoses exist1,4,20. Specifically, although included in the current definition of AHF, levels of natriuretic peptides can be elevated in respiratory disease and other acute conditions such as pulmonary embolism, sepsis, and anaemia21,22,23,24.

Any acute condition can be further complicated by the external factors present in emergency settings, such as high ambient noise and restrictive space, limiting a clinician's ability to position the patient optimally for examination. Furthermore, the frequently atypical features of very severe pathology (in particular valvular disease), and the time pressures imposed by an acutely deteriorating patient can contribute to poor outcomes. These factors are further confounded by the presence of concomitant pathologies in the increasingly ageing patient population25.

Echocardiography and LUS are readily available and widely validated techniques that can be used to reveal anatomical and physiological abnormalities in patients with AHF, which when correctly applied in the acute setting, can improve patient assessment, management, and outcomes (Figs 1,2)26. Unlike other biomarkers used in AHF, echocardiography and LUS can be used to identify not only inadequate cardiac output and/or the presence of congestion, but also the underlying cause, allowing the most appropriate, individualized interventions to be delivered immediately to the patient27. Furthermore, these imaging modalities can be used to monitor the effects of treatment (either beneficial or detrimental), as well as to guide patient disposition and interventions as indicated28. Pocket-sized echocardiography devices are practical for screening, and provide information to clinicians in addition to that gathered from auscultation by a stethoscope alone. When AHF is suspected, an integrative approach is recommended, including determination of cardiopulmonary instability and evaluation of congestion (pulmonary and peripheral) using a combination of techniques4. When image quality is inadequate, either transoesophageal echocardiography or the use of contrast should be considered.

Figure 1: Lung and pleural ultrasonography.
Figure 1

a | Normal lung with pleural line, and ribs (*) with shadowing. b | Pulmonary oedema with multiple vertical B-lines (arrows) arising from the pleural line. c | Diaphragmatic view with spine ending at the level of the diaphragm, with no pleural effusion. d | Pleural effusion seen as anechoic (echo-free) space above the diaphragm with atelectatic lung. Spine can be visualized beyond the diaphragm owing to the effusion.

Figure 2: Echocardiographic methods to estimate left atrial pressure.
Figure 2

The upper panels show the echocardiographic scan of a patient aged 45 years admitted to hospital with dyspnoea owing to severe acute respiratory failure. a | Transthoracic echocardiogram (TTE) of the mitral inflow pattern showing a normal early (E) and late (A) transmitral flow pattern. b | Tissue Doppler imaging (TDI) of the lateral mitral valve annulus from the same patient; S is systolic annular velocity, E′ is early annular diastolic velocity, and A′ is late annular diastolic velocity (related to atrial contraction). c | Pulmonary venous Doppler (transesophageal echocardiography) demonstrating a dominant systolic wave (S) and smaller diastolic wave (D), with a normal deceleration time. The E/A ratio is >1 and the E/E′ is <8 cm/s with a dominant S wave on pulmonary vein, consistent with a normal left atrial pressure. The lower panels show the echocardiographic scan of a female patient aged 59 years admitted with dyspnoea owing to severe left ventricular dysfunction with pulmonary oedema. d | TTE of the mitral inflow pattern showing a dominant E wave with E/A ratio >2. e | TDI of the septal mitral valve annulus with a very low early diastolic velocity (E′), and f | pulmonary venous Doppler (transoesophageal echocardiography) showing a blunted systolic wave (S) and dominant diastolic wave (D). The E/E′ is 16.3 cm/s, and dominant D wave on pulmonary venous Doppler with D deceleration time <150 ms are consistent with an elevated left atrial pressure.

Lung ultrasonography

Based on the interpretation of a number of artefacts, specific ultrasonography appearances, and their distribution (Fig. 1), LUS allows for a rapid point-of-care evaluation of a number of conditions, including pulmonary oedema, lung consolidation, pleural effusion, and pneumothorax29. High intra-rater and inter-rater reproducibility, ease of learning, short exam duration (<5 min), and the noninvasive nature of this technique makes it an advantageous point-of-care tool30,31,32. LUS is increasingly used in the acute care setting, and has improved diagnostic accuracy compared with clinical assessment and chest radiography for the identification of a cardiac aetiology in patients presenting to the emergency department with undifferentiated dyspnoea33.

Interstitial fluid and pulmonary oedema

Quantification of B-lines (vertical artefacts that result from an increase in interstitial density; Fig. 1b) has been shown to be useful for the diagnosis, monitoring, and risk assessment of patients with known or suspected AHF34,35,36. Either curvilinear or phased array transducers can be used, typically at an imaging depth of 18 cm. Although the assessment of eight or more anterior and lateral thoracic zones (four on each hemithorax) has been recommended in a consensus statement29, a subsequent study demonstrated high diagnostic accuracy with examination of only six thoracic regions33. The visualization of three or more B-lines in two or more intercostal spaces bilaterally should be considered diagnostic for pulmonary oedema, with sensitivity of 94% (95% CI 81–98%) and specificity of 92% (95% CI 84–96%)33,37. By contrast, physical examination and chest radiography have a sensitivity of only 62% (95% CI 61–64%) and 57% (95% CI 55–59%), and a specificity of 68% (95% CI 67–69%) and 89% (95% CI 88–90%) for a diagnosis of pulmonary oedema, respectively38. The presence of multiple bilateral B-lines in AHF has been well-correlated with natriuretic peptide levels, and only variably correlated with pulmonary capillary wedge pressure and measures of extravascular lung water30,33,35,39,40,41. Given that studies to assess the incremental diagnostic value of LUS compared with natriuretic peptides for the identification of AHF in patients with dyspnoea reported variable results in different cohorts, this topic warrants further investigation31,33,42. The number of B-lines is thought to decrease with treatment for AHF and, therefore, this technique is potentially useful in the monitoring of pulmonary oedema in response to therapy35,36. For serial assessments, patient positioning (sitting versus supine) should be kept consistent43. Importantly, a higher number of B-lines on LUS at the time of discharge from hospital might help to identify patients with heart failure who have a worse prognosis36.

Pleural effusion

Similarly to B-lines, the presence of pleural effusions can be assessed using curvilinear or phased array transducers in the posterior–axillary line34 (Fig. 1d). Current data regarding the diagnostic utility of pleural effusions identified on ultrasonography in patients with AHF are less robust, but have been reported with sensitivities of 79–84% and specificities of 83–98% in small studies of patients with dyspnoea44,45.

Pneumothorax

LUS can be used to exclude pneumothorax in the area scanned with higher sensitivity than supine chest radiography by recognizing lung sliding, a slight horizontal movement of the pleural line with respiration; see Supplementary information S1 (video)46. In the setting of a pneumothorax, lung sliding is absent in the affected area of the chest. At the border of a pneumothorax, a transition point between normal lung surface (with lung sliding) and pneumothorax (without lung sliding) can sometimes be identified47. This so-called 'lung point' confirms the diagnosis. Lung sliding might be absent in several other pathological conditions (such as pleural adhesions or selective mainstem intubation) and, therefore, should not be used in isolation to make the diagnosis of pneumothorax, but rather in conjunction with the full range of sonographic features46.

Differential diagnosis and potential pitfalls

The major questions when using LUS for the assessment of patients with possible AHF include whether there is evidence of pulmonary oedema (such as multiple bilateral B-lines), whether there are other findings suggestive of AHF (such as pleural effusion), and finally, whether there are findings of alternate or concurrent conditions (such as pulmonary consolidation or pneumothorax). Despite its apparent simplicity, a number of caveats exist for the use of LUS. First, B-lines can resolve rapidly in response to treatment, and, therefore, LUS data must be interpreted in the context of previous interventions35. Second, B-lines can be seen in a number of pulmonary conditions, including pulmonary fibrosis or interstitial lung disease, acute respiratory distress syndrome, and pneumonitis29. The observation of B-lines together with other LUS abnormalities might indicate that two pathologies coexist, or that the B-lines are an expression of pathology other than AHF (for example, acute respiratory distress syndrome, or pulmonary oedema in patients receiving haemodialysis)48. Third, large pleural effusions might interfere with B-line quantification in the affected thoracic zones and induce lung consolidation (Fig. 1d). Together, these considerations outline why LUS should not be used in isolation, but rather integrated into clinical and laboratory assessment33,49,50.

Echocardiography in AHF

Driven by progressive advances in ultrasonography technology and an expanding evidence base, the use of echocardiography has extended beyond the traditional application in stable patients to become widespread in the acute and emergency settings51,52. Mirroring the concept of critical care, echocardiography is increasingly used as a tool to guide management of the most acutely unwell patients wherever they present along the management pathway. Pocket-sized devices have been recommended in the emergency department, intensive care unit, and coronary units for fast initial qualitative screening of ventricular and valvular function, pericardial and pleural effusion, or extravascular lung water. However, owing to the known limitations of this technique, they are not intended as a substitution for comprehensive echocardiography26,53. Remote expert review of images is now a possibility, and in the future, telemedicine will probably have an important role in guiding the assessment and management of these acutely unwell patients.

Echocardiography is used in AHF to help to confirm diagnosis, delineate potential underlying causes, identify associated pathophysiology, and monitor the response to therapy28,54. Echocardiography can also be used to guide specialist interventions in the catheter laboratory or operating room55,56,57. Furthermore, echocardiography can address several major questions, including whether a patient has a cardiac cause for their symptoms and signs, the severity of the cardiac impairment and its physiological effect, whether there is an underlying reversible cause, what the most appropriate initial treatment is, and how the patient responds to treatment.

Guidelines recommend immediate echocardiographic assessment for patients with suspected AHF with haemodynamic instability1,4; however, interpretation of echocardiographic data in these acutely unwell patients can be extremely complex (Table 1). First, the finding of a structurally or functionally abnormal heart does not necessarily mean the cause of dyspnoea is cardiac-related. Second, patients might be misdiagnosed as having primary respiratory disease, even in the presence of very severe cardiac pathology27,58. Third, substantial cardiac and respiratory disease might coexist, and determining the degree of cardiac contribution is frequently challenging in this setting59. These considerations are further compounded by the relative paucity of high-quality evidence to support the use of echocardiography techniques in the acute arena, as they have been predominantly validated in the outpatient clinic.

Table 1: Challenges in using echocardiography to determine the underlying cause of AHF

Left-sided disease and elevated LAP

Dyspnoea resulting from left-sided cardiac disease is likely to be associated with elevated left atrial pressure (LAP) and pulmonary oedema. Historically, pulmonary capillary wedge pressure has been measured using a pulmonary artery catheter as a substitute for LAP measurement60,61,62. The use of the pulmonary artery catheter has greatly declined over the past decade, owing to a number of studies that showed potential harm or no improved outcomes in the perioperative and critical care settings63. Although absolute pressure values cannot be measured using echocardiography, a drive has occurred to find an echocardiography-derived parameter that can be used to estimate the LAP noninvasively. Indices that have been proposed include interrogation of the transmitral left ventricular (LV) filling pattern (E/A ratio, E wave deceleration time, and the isovolumic relaxation time), pulmonary venous Doppler diastolic deceleration time (Fig. 2), M-mode colour Doppler propagation velocities, the time interval between the onset of early diastolic mitral inflow (E) and annular early diastolic velocity (e′) by tissue Doppler imaging, and the E/e′ ratio64,65,66,67,68,69. None of these measures has been well-validated in the context of emergency medicine70,71; they all present technical challenges that must be carefully considered for accurate interpretation, and provide only estimates of a potential range of corresponding LAP values. Even when used in combination (as proposed in critical care), they can at best only indicate that the LAP is probably very high or normal.

LV ejection fraction has been the main parameter used for the diagnosis, treatment, and stratification of patients with heart failure. However, this parameter has several limitations that are particularly relevant in the acute setting, such as load-dependency and inotropy-dependency72,73. Even in the absence of high-quality 2D images, Doppler abnormalities in transmitral filling might provide an early indicator of important pathology72,74,75,76.

Unlike LUS, echocardiography might be challenging to perform well and interpret accurately, as a number of considerations add to the complexity of its application in the acute setting. First, in all parameters described for LAP estimation, the confounding factors imposed by critical illness (changes in heart rate, cardiac output, LV compliance, and volume and ventilatory status) have not been fully evaluated. Second, not only might patients with a relatively normal LAP have radiographic and sonographic evidence of pulmonary oedema, but conversely, patients with chronically elevated LAP might have no evidence of pulmonary oedema. Similarly to LUS, however, the echocardiographic findings should be integrated with those from clinical examination, laboratory investigations, and lung imaging data (radiographic and/or sonographic), and be assessed within the clinical context. The main value of echocardiography in this setting is to diagnose or exclude an underlying cardiac cause for dyspnoea and guide subsequent interventions.

Right-sided disease: pulmonary embolism

The diagnosis of pulmonary embolism can be challenging, because symptoms and signs are nonspecific. The transthoracic echocardiogram is normal in approximately 50% of unselected patients with acute pulmonary embolism, and has a sensitivity of 50–60% and specificity of 80–90%77. Therefore, other investigations are used to confirm the diagnosis, with echocardiography used as a complementary imaging technique19. The principal indirect echocardiographic findings are nonspecific, and include right heart dilatation, right ventricular (RV) hypokinesis (with or without apical sparing), abnormal septal motion, and inferior vena cava dilatation78 (Fig. 3a). Secondary tricuspid regurgitation might be present, allowing estimation of pulmonary arterial systolic pressure using the simplified Bernoulli equation79 (Fig. 3b). Given that the right ventricle can generate a pulmonary artery systolic pressure of only ≤60 mmHg acutely, a higher pressure suggests a more chronic process (either multiple repeated episodes or chronic pulmonary parenchymal disease, with or without pulmonary embolism)80. Although the peak tricuspid regurgitation gradient is the most commonly used parameter to assess pulmonary artery systolic pressure in clinical practice, difficulties in the detection of good tricuspid regurgitation envelope might occur. Pulsed Doppler recordings of pulmonary valve flow acceleration time, pre-ejection period, and ejection time at the RV outflow tract can also be used to estimate pulmonary artery pressure and resistance81,82.

Figure 3: Echocardiographic features in patients presenting with severe haemodynamic impairment.
Figure 3

a | Transthoracic echocardiography in a patient with acute-on-chronic pulmonary embolism from an apical four-chamber view showing a severely dilated right ventricle (RV), and b | increased pulmonary systolic pressure estimated by applying the simplified Bernoulli equation using the measured tricuspid regurgitation peak velocity (50 mmHg; asterisk). c | Parasternal short axis view showing RV and left ventricle (LV) surrounded by a circumferential pericardial effusion (asterisk) that induced tamponade. d | Transoesophageal echocardiography (transgastric short-axis view) of a patient aged 42 years admitted with cardiogenic shock presenting with ST-segment elevation in the anterolateral electrocardiogram leads. Coronary angiography showed critical three-vessel coronary artery disease. The LV is severely dilated, and there is evidence of previous myocardial infarction, shown by the presence of thinned and akinetic myocardium (dotted red line). LA, left atrium; RA, right atrium.

Pericardial collection and tamponade

Echocardiography is pivotal for recognition of the haemodynamic consequences of a pericardial collection (Fig. 3c), allowing demonstration of features of tamponade including right atrial and/or RV diastolic collapse, in addition to guiding pericardiocentesis83. A number of potential pitfalls exist when interpreting the echocardiographic features of tamponade in the acute setting. These pitfalls include the effects of positive pressure ventilation (reversal of changes in transvalvular flows) and localized collections, in particular after cardiac surgery when substantial haemodynamic compromise might be present, even in the absence of echocardiographic features of tamponade84.

Monitoring of therapy

Echocardiography is not recommended for the monitoring of therapy in patients with AHF in the absence of cardiogenic shock4,9,11, given the complexity of LAP estimation using echocardiography, its lack of association with pulmonary congestion and symptoms, and superiority of natriuretic peptide levels in monitoring response to therapy. An emerging area in which echocardiography might be of use is in risk stratification before discharge from hospital. In patients with AHF with dyspnoea, persistent pulmonary congestion before discharge (demonstrated on LUS) has been shown to be an independent predictor of rehospitalization for AHF at 6 months after discharge36.

Cardiogenic shock

Cardiogenic shock is the most severe manifestation of AHF. Although relatively uncommon, the published prevalence (5% of patients with AHF) varies according to the point of initial contact and management (1–2% of patients with AHF in the prehospital or emergency setting versus 29% in intensive care)4,9,10,16. Precise definitions of cardiogenic shock can vary; however, the syndrome generally results from inadequate cardiac output for peripheral organ requirements85,86. Cardiogenic shock can manifest as hypotension despite adequate filling (with or without vasopressors), altered mentation, cool peripheries, oliguria, hyperlactataemia, metabolic acidaemia, and low mixed venous oxygen saturation86. In addition to standard evaluation of critically ill patients in parallel with resuscitation, echocardiography is mandated immediately in patients with cardiogenic shock, because without identification and treatment of the underlying cause, the outcome is usually fatal9,85 (Fig. 3d). Additional information that should be obtained from echocardiography includes estimation of stroke volume and cardiac output levels, because these data can provide guidance on how to maximize the cardiac output at the lowest filling pressures (see Supplementary information S2 (table)). These measurements should be taken during the echocardiogram, and should be performed repeatedly to monitor the response to therapeutic interventions and minimize potentially injurious treatment. Every study must be interpreted in the context of the level of inotropic and ventilatory support, as well as metabolic and arterial blood gas status, because these variables might have profound effects on echocardiographic findings.

Assessment of volume status. The physiological basis of providing 'optimal' filling in cardiogenic shock is that a critical decrease in intravascular-stressed volume reduces the difference between mean systemic venous and right atrial pressure, thereby limiting stroke volume. Although frequently used, invasive static pressure monitoring is not helpful for determining whether an individual patient is volume-responsive87,88. Static echocardiographic parameters are widely used to predict volume responsiveness in critically ill patients (Fig. 4); however, their use requires that a number of strict criteria (relating to the patient, their underlying pathology, and medical interventions) are met, otherwise the investigation becomes invalid (see Supplementary information S3 (table)). Similarly, although thought to be superior, dynamic echocardiographic parameters to predict volume responsiveness are valid only in fully mechanically ventilated patients in sinus rhythm and without chronic heart disease89. In the presence of cardiac disease (either left-sided and/or right-sided), these measurements can be misleading and should not be used. Conversely, tolerance to volume loading among different patients is variable. The conventional teaching to increase volume in RV failure has not been upheld by findings published in the past 3 years90,91. Physiological models suggest that in some patients, progressive fluid loading leads to a plateauing of cardiac output, with a progressive increase in pulmonary artery occlusion pressure. In addition, higher volume is associated with worse outcome in critically ill patients92,93,94.

Figure 4: Static 2D echocardiography parameters are used to evaluate potential volume responsiveness.
Figure 4

The upper panels show a patient who is severely hypovolaemic, and responded to volume loading with an increase in stroke volume. a | Short-axis view of the left ventricle (LV) is shown, where the left ventricular end-diastolic area (dotted red circle) is small. b | From a subcostal view, an obliterated inferior vena cava (IVC) at end-expiration (<1 cm) can be observed. The lower panels show a patient who, according to static 2D echocardiography parameters, would not be predicted to respond to volume loading by increasing stroke volume. c | Short-axis view of the LV with a normal left ventricular end-diastolic area (dotted red circle). d | Dilated IVC at end-expiration.

Inotropes and vasoactive agents. Although inotropes and vasopressors are commonly used to improve cardiac output and blood pressure in patients with cardiogenic shock, there is currently insufficient evidence to support the use of any particular agent in this context9,95,96. Dobutamine is generally the first-line inotrope of choice in the clinic9,95,96. The detrimental effects of positive inotropic agents have been extensively described in the literature97,98, and their use should, therefore, be restricted to the shortest possible duration and the lowest dose, both individualized to the patient. Although little guidance exists on how inotrope treatment should be individualized, echocardiography might be helpful in certain scenarios.

First, not all patients with cardiac disease respond to escalating doses of dobutamine by increasing their stroke volume; in some patients, dobutamine can result in an increase in the total isovolumic time (tIVT)99. Echocardiographic identification of an abnormally prolonged tIVT with dobutamine use, or an increase in tIVT in response to escalating inotropic support might indicate that inotropes are directly impairing myocardial performance, thereby prompting a reduction in dose or a change in treatment strategy99,100,101 (Fig. 5). Second, the combination of LV end-diastolic pressure (LVEDP) and low aortic root pressure might result in a mismatch of coronary perfusion and myocardial oxygen demand. If untreated, this mismatch can result in type 2 myocardial infarction102 (Fig. 3d). Echocardiographic demonstration of a dominant or isolated A wave on transmitral Doppler in combination with postejection shortening can also be diagnostic (Fig. 6a,b), and indicates that aortic root pressure should be increased and/or LVEDP reduced103,104. Third, physiological studies have demonstrated that the combination of RV ischaemia and increased RV afterload is particularly injurious to RV performance, resulting in a fall in systemic blood pressure and cardiac output levels105. Echocardiography can be used to estimate pulmonary artery systolic pressure and pulmonary vascular resistance, as well as measure RV dimensions and performance106. Echocardiographic identification of high pulmonary vascular resistance with or without pulmonary hypertension in combination with RV dysfunction in cardiogenic shock might necessitate the introduction of a pressor agent plus treatment to reduce RV afterload90,107 (Fig. 6c,d). Finally, in a patient with falling cardiac output levels despite escalating inotropic support, echocardiography can help to diagnose LV outflow tract obstruction (with or without associated mitral regurgitation)27,108. Treatment in this context involves reduction or cessation of positive inotropic agents, in combination with volume and pressor support.

Figure 5: Echocardiography-guided cardiac output optimization using pulsed-wave Doppler imaging.
Figure 5

a,b | Transmitral and transaortic pulsed-wave Doppler imaging at 90 bpm. c,d | Transmitral and transaortic pulsed-wave Doppler imaging at 100 bpm. The filling time (FT) is measured from the start to the end of transmitral filling, and the ejection time (ET) from the start to the end of aortic ejection. The total ejection (t–ET) and filling (t–FT) periods are then derived as the product of the corresponding time interval and heart rate, and expressed in s/min. t–IVT (also in s/min) is calculated as 60–(t–FT + t–ET). A heart rate reduction of 10 bpm resulted in a reduction of t–IVT from 16.8 s/min to 10.0 s/min, and a corresponding increase in cardiac output from 3.6 l/min to 5.6 l/min.

Figure 6: The haemodynamic effects of thrombosis (coronary and pulmonary) as demonstrated by echocardiography.
Figure 6

a | Early features of myocardial ischaemia can be demonstrated by the presence of prolonged long-axis shortening, measured by M-mode echocardiography across the base of the left ventricle (post-ejection shortening; arrow). b | Prolonged left ventricular wall tension suppresses early transmitral filling, resulting in an isolated late-diastolic transmitral A wave. c | Increased right ventricular afterload leads to a reduction in right ventricular systolic function, as demonstrated by tricuspid annular plane systolic excursion on M-mode echocardiography across the tricuspid annulus. d | A substantial increase in pulmonary vascular resistance might be associated with a midsystolic notch (arrows) on pulmonary valve pulsed-wave Doppler ejection wave and a short pulmonary valve acceleration time (78 ms; red lines).

Cardiac arrest. The most extreme presentation of cardiogenic shock is cardiac arrest. International evidence- based guidelines recommend the use of echocardiography to diagnose or exclude some of the causes of arrest109. However, echocardiography should not affect the delivery of high-quality cardiopulmonary resuscitation, and specific training in advanced cardiovascular life support is required, even for experienced practitioners. As images are obtained and recorded only during the pulse/rhythm check, studies performed during cardiac arrest are strictly time-limited, and therefore are dissimilar to comprehensive studies that use only focused 2D imaging aimed at diagnosis or exclusion of potentially reversible causes in a simple, binary manner. The pathology leading to arrest is likely to be extreme (tamponade, massive pulmonary embolism, severe LV and/or RV dysfunction, myocardial infarction/ischaemia, hypovolaemia, or tension pneumothorax) and fairly easy to diagnose without more sophisticated echocardiographic techniques. Whether the use of echocardiography in cardiac arrest (and as part of care after resuscitation) can improve outcomes is unknown, but its application in the prehospital setting has been found to change management strategies in up to 60% of patients110,111.

Acute mechanical circulatory support. The indications for mechanical circulatory support (MCS) in the acute setting are constantly changing112,113. Intra-aortic balloon pumps are no longer routinely recommended for cardiogenic shock114. A range of new percutaneous ventricular assist devices are available, in addition to extracorporeal membrane oxygenation (ECMO). These techniques can be used as a bridge to recovery or for longer-term support, and differ not only in terms of their technical aspects, but the degree and type of support provided (LV and/or RV support, with or without the addition of respiratory support)115,116,117,118,119,120. Echocardiography is critical for successful implementation of acute MCS121,122 (Table 2). MCS is not a treatment per se, but instead a supportive therapy for patients awaiting treatment or resolution of the underlying pathological process. As in all cases of AHF, the most important role of echocardiography is to diagnose the underlying cardiac cause. When the decision to institute MCS is made, echocardiography is then used to corroborate the decision regarding the type and level of support required. Although clear echocardiography parameters have been used to guide longer-term MCS for both the left and right heart123,124, these parameters are not yet available for devices designed for short-term use. Furthermore, clear contraindications to MCS exist that can be diagnosed only using echocardiography. Echocardiography is used in the initiation of MCS, including the use of vascular ultrasonography to guide safe vessel cannulation and steer device or cannula placement. Echocardiography is subsequently used to monitor MCS by ensuring the goals of support are met, and for detecting complications and assessing tolerance to assistance121. Unfortunately, peripheral ECMO can paradoxically worsen cardiac function by increasing LV afterload. Although a number of echocardiographic parameters exist that might indicate this complication (including lack of aortic valve opening, biphasic retrograde flow across the mitral valve in diastole, and retrograde systolic pulmonary venous flow; Fig. 7), the inherent limitations of echocardiography in estimating LAP and LVEDP, especially when the heart is partially bypassed, makes this strategy particularly challenging122. Echocardiography can be used, however, to guide interventions to ensure that the heart is adequately offloaded. Finally, a number of echocardiographic parameters are used in conjunction with clinical and haemodynamic assessment to predict which patients might be successfully weaned off MCS125,126.

Table 2: Echocardiography for acute mechanical circulatory support
Figure 7: Echocardiographic features in patients receiving extracorporeal support.
Figure 7

Transthoracic echocardiography in a patient with severe respiratory failure receiving venovenous extracorporeal membrane oxygenation (ECMO). a | Parasternal long axis M-mode echocardiography across the mitral valve showing systolic anterior motion of the mitral valve leaflets (arrow). b | This motion was associated with substantial left ventricular intracavity gradient of 125 mmHg (asterisk). c | A complication of ST-segment elevation myocardial infarction requiring peripheral ECMO is revealed on M-mode echocardiography; papillary muscle rupture had resulted in a flail anterior mitral valve leaflet (white arrow) with associated torrential mitral regurgitation. The increase in left ventricular afterload from ECMO has resulted in failure of the left ventricle (LV) to eject, with a persistently closed aortic valve (AV; red arrow) and stasis of blood in the aortic root. d | Reversal of systolic pulmonary venous flow (arrows) in a patient receiving peripheral venovenous ECMO, suggesting inadequate offloading of the LV.

Other indications

Transoesophageal echocardiograpy can also be used in the acute setting in patients with dynamic mitral regurgitation (see Supplementary information S4 (figure)). Furthermore, features of infective endocarditis caused by aortic prostheses or a device can be demonstrated using transoesophageal echocardiography (see Supplementary information S5 (figure)).

Quality assurance

A detailed overview of the necessary organizational structure and processes for use of ultrasonography and echocardiography in the acute setting is beyond the scope of this Review, and has been published previously26,127,128,129,130. However, when used in routine clinical care, training, education, protocols, and ongoing certification of practitioners are required, which should all be performed within existing governance structures.

Conclusions

Echocardiography and LUS can assist in the rapid assessment of patients with acute dyspnoea and hypotension, and have the potential to transform the way in which clinicians assess and manage critically ill patients with AHF and cardiogenic shock (Table 3). The current AHF guidelines are cautious in recommendations for the widespread use of advanced echocardiography techniques in the acute care setting because robust applicability data are lacking, interpretation of findings requires highly specialized, in-depth knowledge of cardiac pathophysiology, and there is potential for harm by injudicious application in this patient population. The opportunities to improve diagnostic accuracy, reduce delays in treatment, and improve outcomes through the use of advanced echocardiography need to be further explored.

Table 3: Proposed initial focused cardiac and lung ultrasonography assessment for patients with suspected AHF in acute care setting

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Author information

Author notes

    • Susanna Price
    • , Elke Platz
    •  & Louise Cullen

    These authors contributed equally to this work.

Affiliations

  1. Royal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

    • Susanna Price
  2. Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.

    • Elke Platz
  3. Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Butterfield St & Bowen Bridge Road, Herston, Queensland 4029, Australia.

    • Louise Cullen
  4. University of Pavia Intensive Care Unit 1st Department, Fondazione Policlinico IRCCS San Matteo, Viale Camillo Golgi 19, 27100 Pavia, Italy.

    • Guido Tavazzi
  5. Department of Emergency and Critical Care Medicine, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, 90419 Nürnberg, Germany.

    • Michael Christ
  6. Department of Cardiology, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

    • Martin R. Cowie
  7. Coronary Care Unit and Heart Failure Program, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161, USA.

    • Alan S. Maisel
  8. Critical Care Department, Consorci Sanitari Integral, Hospital Sant Joan Despí Moisès Broggi and Hospital General de l'Hospitalet, University of Barcelona, Grand Via de las Corts Catalanes 585, 08007 Barcelona, Spain.

    • Josep Masip
  9. Emergency Department, Hospital Clínic de Barcelona, Carrer de Villarroel 170, 08036 Barcelona, Spain.

    • Oscar Miro
  10. BHF Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.

    • John J. McMurray
  11. Emergency Medicine, Baylor College of Medicine, Scurlock Tower, 1 Baylor Plaza, Houston, Texas 77030, USA.

    • W. Frank Peacock
  12. Emergency Department, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos, Calle del Prof Martín Lagos, 28040 Madrid, Spain.

    • F. Javier Martin-Sanchez
  13. Emergency Department, Sant'Andrea Hospital, Faculty of Medicine and Psychology, LaSapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

    • Salvatore Di Somma
  14. Centro Nacional de Investigaciones Cardiovasculares and Department of Cardiology, Hospital 12 de Octubre, Avenida de Córdoba, 28041 Madrid, Spain.

    • Hector Bueno
  15. Klinikum Ludwigshafen, Institut für Herzinfarktforschung Ludwigshafen, Bremserstraße 79, 67063 Ludwigshafen am Rhein, Germany.

    • Uwe Zeymer
  16. Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

    • Christian Mueller

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Contributions

S.P., L.C., and G.T. researched data for the article. S.P., E.P., and G.T. wrote the manuscript. S.P., L.C., E.P., J.M., and W.F.P. substantially contributed to the discussion of content. All the authors reviewed and edited the manuscript before submission.

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Supplementary information

Videos

  1. 1.

    Normal lung sliding

    Normal lung sliding (back and forth movement with respiration along the pleural line) rules out a pneumothorax in the scanned area of the chest.

PDF files

  1. 1.

    Supplementary table 1

    Common challenges in filling pressure assessment in the acute setting

  2. 2.

    Supplementary table 2

    Common challenges in volume status assessment in the acute setting

  3. 3.

    Supplementary figure 1

    Transoesophageal echocardiography in a patient with dynamic mitral regurgitation.

  4. 4.

    Supplementary figure 2

    Echocardiographic features of infective endocarditis demonstrated using transoesophageal echocardiography.

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https://doi.org/10.1038/nrcardio.2017.56

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