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Genetics of CVD in 2017

Expanding the spectrum of CVD genetics

Nature Reviews Cardiology volume 15, pages 77–78 (2018)Cite this article

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In 2017, genetic research on cardiovascular disease (CVD) produced seemingly paradoxical findings. Thanks to the continuous upscaling of genotyping and sequencing data, researchers have discovered that whereas numerous genetic variants among the general population can increase CVD risk, an individual can tolerate most severe genetic alterations.

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Figure 1: Evolution of genetic concepts underlying risk of cardiovascular disease.

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Acknowledgements

The author is supported by grants from the Fondation Leducq (CADgenomics: understanding CAD genes, 12CVD02), the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (e:AtheroSysMed, grant 01ZX1313A-2014), the German Center of Cardiovascular Research (DZHK) Munich Heart Alliance, and the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456. Further grants were received from the DFG as part of the Sonderforschungsbereich CRC 1123 (B2).

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  1. Heribert Schunkert is at Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, 80636 Munich, Germany.,

    Heribert Schunkert

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Correspondence to Heribert Schunkert.

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Schunkert, H. Expanding the spectrum of CVD genetics. Nat Rev Cardiol 15, 77–78 (2018). https://doi.org/10.1038/nrcardio.2017.209

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