In 2017, genetic research on cardiovascular disease (CVD) produced seemingly paradoxical findings. Thanks to the continuous upscaling of genotyping and sequencing data, researchers have discovered that whereas numerous genetic variants among the general population can increase CVD risk, an individual can tolerate most severe genetic alterations.
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The author is supported by grants from the Fondation Leducq (CADgenomics: understanding CAD genes, 12CVD02), the German Federal Ministry of Education and Research (BMBF) within the framework of the e:Med research and funding concept (e:AtheroSysMed, grant 01ZX1313A-2014), the German Center of Cardiovascular Research (DZHK) Munich Heart Alliance, and the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456. Further grants were received from the DFG as part of the Sonderforschungsbereich CRC 1123 (B2).
The author declares no competing financial interests.
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Schunkert, H. Expanding the spectrum of CVD genetics. Nat Rev Cardiol 15, 77–78 (2018). https://doi.org/10.1038/nrcardio.2017.209
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