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Air pollution and cardiovascular disease: a window of opportunity

The recent publication of The Lancet Commission on pollution and health is a watershed moment for one of the greatest challenges to cardiovascular health. In this Comment article, we discuss the global burden of air pollution on cardiovascular health.

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Figure 1: Conceptual diagram illustrating a combined population-level and individual-level approach to mitigating air pollution exposures and protecting cardiovascular health.


  1. 1

    GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390, 1345–1422 (2017).

  2. 2

    Landrigan, P. J. et al. The Lancet Commission on pollution and health. Lancet (2017).

  3. 3

    Brook, R. D. et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121, 2331–2378 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Cosselman, K. E., Navas-Acien, A. & Kaufman, J. D. Environmental factors in cardiovascular disease. Nat. Rev. Cardiol. 12, 627–642 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Newby, D. E. et al. Expert position paper on air pollution and cardiovascular disease. Eur. Heart J. 36, 83–93 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Ruckerl, R., Schneider, A., Breitner, S., Cyrys, J. & Peters, A. Health effects of particulate air pollution: a review of epidemiological evidence. Inhal. Toxicol. 23, 555–592 (2011).

    Article  Google Scholar 

  7. 7

    Environmental Protection Agency Office of Air and Radiation. The Benefits and Costs of the Clean Air Act from 1990 to 2020, Final Report — Rev. A. EPA

  8. 8

    Shin, H. H. et al. Meta-analysis methods to estimate the shape and uncertainty in the association between long-term exposure to ambient fine particulate matter and cause-specific mortality over the global concentration range. Risk Analysis 36, 1813–1825 (2016).

    Article  Google Scholar 

  9. 9

    Anderson, H. R. Implications for the science of air pollution and health. Lancet Respir. Med. 5, 916–918 (2017).

    Article  Google Scholar 

Download references


R.V. is supported by grant 1R21HL140474. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Correspondence to Michael B. Hadley.

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The authors declare no competing financial interests.

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Hadley, M., Vedanthan, R. & Fuster, V. Air pollution and cardiovascular disease: a window of opportunity. Nat Rev Cardiol 15, 193–194 (2018).

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