Association between the gut microbiome and atherosclerosis

The gut microbiota has been associated with many different disorders, including cardiovascular diseases. A new study by Jie and colleagues is the first large case–control study to examine directly the enrichment of certain communities of gut bacteria in patients with atherosclerotic cardiovascular disease compared with control individuals.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Experimental design.


  1. 1

    Jie, Z. et al. The gut microbiome in atherosclerotic cardiovascular disease. Nat. Commun. 8, 845 (2017).

    Article  Google Scholar 

  2. 2

    Jonsson, A. L. & Backhed, F. Role of gut microbiota in atherosclerosis. Nat. Rev. Cardiol. 14, 79–87 (2017).

    CAS  Article  Google Scholar 

  3. 3

    Org, E., Mehrabian, M. & Lusis, A. J. Unraveling the environmental and genetic interactions in atherosclerosis: central role of the gut microbiota. Atherosclerosis 241, 387–399 (2015).

    CAS  Article  Google Scholar 

  4. 4

    Li, D. Y. & Tang, W. H. W. Gut microbiota and atherosclerosis. Curr. Atheroscler. Rep. 19, 39 (2017).

    Article  Google Scholar 

  5. 5

    Tang, W. H. et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575–1584 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Zhu, W. et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165, 111–124 (2016).

    CAS  Article  Google Scholar 

  7. 7

    Wang, Z. et al. Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163, 1585–1595 (2015).

    CAS  Article  Google Scholar 

  8. 8

    Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079–1094 (2015).

    CAS  Article  Google Scholar 

  9. 9

    Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258–1270 (2012).

    CAS  Article  Google Scholar 

Download references


The authors are supported by NIH grants HL30568 and HL28481.

Author information



Corresponding author

Correspondence to Aldons J. Lusis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Barrington, W., Lusis, A. Association between the gut microbiome and atherosclerosis. Nat Rev Cardiol 14, 699–700 (2017).

Download citation

Further reading


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing