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Imaging

Perivascular fat — an unheralded informant of coronary inflammation

A novel image-analysis method using standard CT imaging demonstrates that changes in the CT signal of coronary perivascular adipose tissue are associated with the degree of inflammation in adjacent coronary plaques. This exciting development might become a useful adjuvant clinical tool, although further validation and prospective outcome studies are required.

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References

  1. 1

    Dweck, M. R. et al. Imaging of coronary atherosclerosis - evolution towards new treatment strategies. Nat. Rev. Cardiol. 13, 533–548 (2016).

    Article  Google Scholar 

  2. 2

    Antonopoulos, A. S. et al. Detecting human coronary inflammation by imaging perivascular fat. Sci. Transl. Med. 9, eaal2658 (2017).

    Article  Google Scholar 

  3. 3

    Joshi, N. V. et al. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet 383, 705–713 (2014).

    Article  Google Scholar 

  4. 4

    Tarkin, J. M. et al. Detection of atherosclerotic inflammation by 68Ga-DOTATATE PET compared to [18F]FDG PET imaging. J. Am. Coll. Cardiol. 69, 1774–1791 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Danad, I., Fayad, Z. A., Willemink, M. J. & Min, J. K. New applications of cardiac computed tomography: dual-energy, spectral, and molecular CT imaging. JACC Cardiovasc. Imaging 8, 710–723 (2015).

    Article  Google Scholar 

  6. 6

    Arbab-Zadeh, A. & Fuster, V. The myth of the 'vulnerable plaque': transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment. J. Am. Coll. Cardiol. 65, 846–855 (2015).

    Article  Google Scholar 

  7. 7

    Stone, G. W. et al. A prospective natural-history study of coronary atherosclerosis. N. Engl. J. Med. 364, 226–235 (2011).

    CAS  Article  Google Scholar 

  8. 8

    Dweck, M. R., Williams, M. C., Moss, A. J., Newby, D. E. & Fayad, Z. A. Computed tomography and cardiac magnetic resonance in ischemic heart disease. J. Am. Coll. Cardiol. 68, 2201–2216 (2016).

    Article  Google Scholar 

  9. 9

    Motoyama, S. et al. Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up. J. Am. Coll. Cardiol. 66, 337–346 (2015).

    Article  Google Scholar 

Download references

Acknowledgements

M.R.D. is supported by the British Heart Foundation (FS/14/78/31020), and is the recipient of the Sir Jules Thorn Award for Biomedical Research 2015. Z.A.F. is supported by NIH grants P01 HL131478, R01 HL071021, R01 HL128056, R01 HL135878, and R01 EB009638.

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Correspondence to Zahi A. Fayad.

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The authors declare no competing financial interests.

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Dweck, M., Fayad, Z. Perivascular fat — an unheralded informant of coronary inflammation. Nat Rev Cardiol 14, 573–574 (2017). https://doi.org/10.1038/nrcardio.2017.127

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