Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Imaging

Focusing light on the vulnerable plaque

A new report has demonstrated the combined use of optical coherence tomography and molecular imaging within human coronary arteries. This combination provides a unique opportunity to look at plaque from a view not previously possible, opening the field for greater understanding of plaque biology in research and clinical practice.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: OCT–NIRAF imaging of a thin-cap fibroatheroma rupture.

References

  1. 1

    Stone, G. W. et al. A prospective natural-history study of coronary atherosclerosis. N. Engl. J. Med. 364, 226–325 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Ughi, G. J. et al. Clinical characterization of coronary atherosclerosis with dual-modality OCT and near-infrared autofluorescence imaging. JACC Cardiovasc. Imaging http://dx.doi.org/10.1016/j.jcmg.2015.11.020, (2016).

  3. 3

    Wang, H. et al. Ex vivo catheter-based imaging of coronary atherosclerosis using multimodality OCT and NIRAF excited at 633 nm. Biomed. Opt. Express 6, 1363–1375 (2015).

    Article  Google Scholar 

  4. 4

    Phipps, J. E. et al. Macrophages and intravascular OCT bright spots: a quantitative study. JACC Cardiovasc. Imag. 8, 63–72 (2015).

    Article  Google Scholar 

  5. 5

    Di Vito, L. et al. Identification and quantification of macrophage presence in coronary atherosclerotic plaques by optical coherence tomography. Eur. Heart J. Cardiovasc. Imaging 16, 807–813 (2015).

    Article  Google Scholar 

  6. 6

    Puri, R. et al. Near-infrared spectroscopy enhances intravascular ultrasound assessment of vulnerable coronary plaque: a combined pathological and in vivo study. Arterioscler. Thromb. Vasc. Biol. 35, 2423–2431 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Yoo, H. et al. Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo. Nat. Med. 17, 1680–1684 (2011).

    CAS  Article  Google Scholar 

  8. 8

    Lee, S. et al. Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels. Circ. Cardiovasc. Interv. 7, 560–569 (2014).

    CAS  Article  Google Scholar 

  9. 9

    Kim, J. B. et al. Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors. Sci. Rep. 6, 22608 (2016).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Stephen J. Nicholls.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Psaltis, P., Nicholls, S. Focusing light on the vulnerable plaque. Nat Rev Cardiol 13, 253–255 (2016). https://doi.org/10.1038/nrcardio.2016.53

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing