Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Anticoagulation therapy

Perioperative anticoagulation—are we at 'a bridge too far'?

The perioperative management of patients with atrial fibrillation who require an elective surgical or other invasive procedure is an area of ongoing uncertainty. Accumulating evidence from observational studies suggests that the use of bridging anticoagulation with heparin, although well-intentioned, might not reduce perioperative thromboembolism and can increase bleeding.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Steinberg, B. A. et al. Use and outcomes associated with bridging during anticoagulation interruptions in patients with atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). Circulation http://dx.doi.org/10.1161/CIRCULATIONAHA.114.011777.

  2. Roger, V. L. et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation 125, e2–e220 (2012).

    PubMed  Google Scholar 

  3. Verma A. et al. 2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation. Can. J. Cardiol. 30, 1114–1130 (2014).

    Article  Google Scholar 

  4. Healey, J. S. et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial. Circulation 126, 343–348 (2012).

    Article  CAS  Google Scholar 

  5. Cullen, M. W. et al. Risks and benefits of anticoagulation in atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. Circ. Cardiovasc. Qual. Outcomes. 6, 461–469 (2013).

    Article  Google Scholar 

  6. Deftereos, S. et al. Oral IIa and Xa inhibitors for prevention of stroke in atrial fibrillation: clinical studies and regulatory considerations. Curr. Clin. Pharmacol. 7, 166–174 (2012).

    Article  CAS  Google Scholar 

  7. Douketis, J. D. et al. Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141 (2 Suppl.), e326S–e350S (2012).

    Article  CAS  Google Scholar 

  8. Birnie, D. H. et al. Pacemaker or defibrillator surgery without interruption of anticoagulation. N. Engl. J. Med. 368, 2084–2093 (2013).

    Article  CAS  Google Scholar 

  9. Siegal, D. et al. Periprocedural heparin bridging in patients receiving vitamin K antagonists: systematic review and meta-analysis of bleeding and thromboembolic rates. Circulation 126, 1630–1639 (2012).

    Article  CAS  Google Scholar 

  10. Douketis, J. D. et al. Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients with an elective surgery or procedure: substudy of the RE-LY trial. Thromb. Haemost. http://dx.doi.org/10.1160/TH14-04-0305.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James D. Douketis.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Douketis, J. Perioperative anticoagulation—are we at 'a bridge too far'?. Nat Rev Cardiol 12, 133–134 (2015). https://doi.org/10.1038/nrcardio.2015.7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2015.7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing