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Decade in review—dyslipidaemia

Resurgence of targets and compounds to treat dyslipidaemia

Over the past decade, we have witnessed the unparalleled success of statins to treat dyslipidaemia. Target identification by Mendelian randomization, human monoclonal antibodies, gene therapy, RNA-based targets, and atherogenic lipoproteins other than LDL cholesterol have fuelled intense development efforts that might bear fruit in the very near future.

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Figure 1: LDL-cholesterol levels achieved by lipid-lowering therapies developed during the past 3 decades in patients with familial hypercholesterolaemia.


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Correspondence to John J. P. Kastelein.

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J.J.P.K. declares that he has acted as a consultant and received honouraria from the following companies: Aegerion, Amgen, AstraZeneca, Atheronova, Boehringer Ingelheim, Catabasis, Cerenis, CSL Behring, Dezima Pharmaceuticals, Eli Lilly, Esperion, Genzyme, Isis, Merck, Novartis, Omthera, Pronova, Regeneron, Sanofi, The Medicines Company, UniQure, and Vascular Biogenics.

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Kastelein, J. Resurgence of targets and compounds to treat dyslipidaemia. Nat Rev Cardiol 11, 629–631 (2014).

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