Dyslipidaemia in 2013

New statin guidelines and promising novel therapeutics

The new ACC/AHA guidelines on treatment of blood cholesterol focus on intensity of statin therapy rather than target levels of lipids. Early studies show substantial reductions in LDL-cholesterol level with antibodies against PCSK9. MicroRNA silencing and gene-repair techniques to treat dyslipidaemia are promising strategies under development.

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Figure 1: microRNA maturation and gene repression.


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Correspondence to Dimitri P. Mikhailidis.

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Competing interests

D. P. Mikhailidis declares that he has given talks, attended conferences, and participated in trials and advisory boards sponsored by Genzyme and MSD. V. G. Athyros declares no competing interests.

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Mikhailidis, D., Athyros, V. New statin guidelines and promising novel therapeutics. Nat Rev Cardiol 11, 72–74 (2014). https://doi.org/10.1038/nrcardio.2013.209

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