Dyslipidaemia in 2013

New statin guidelines and promising novel therapeutics

The new ACC/AHA guidelines on treatment of blood cholesterol focus on intensity of statin therapy rather than target levels of lipids. Early studies show substantial reductions in LDL-cholesterol level with antibodies against PCSK9. MicroRNA silencing and gene-repair techniques to treat dyslipidaemia are promising strategies under development.

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Figure 1: microRNA maturation and gene repression.

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Correspondence to Dimitri P. Mikhailidis.

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D. P. Mikhailidis declares that he has given talks, attended conferences, and participated in trials and advisory boards sponsored by Genzyme and MSD. V. G. Athyros declares no competing interests.

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Mikhailidis, D., Athyros, V. New statin guidelines and promising novel therapeutics. Nat Rev Cardiol 11, 72–74 (2014). https://doi.org/10.1038/nrcardio.2013.209

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