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Vascular disease

Meta-regression of CIMT trials—data in, garbage out

Nature Reviews Cardiology volume 8, pages 128–130 (2011)Cite this article

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Meta-regression of trials using carotid intima–media thickness (CIMT) as a surrogate end point leads to unreliable results owing to heterogeneity in methods, interventions, and outcomes of pooled trials. CIMT will continue to be a worthwhile surrogate trial end point supported by two decades of technical progress and clinical atherosclerosis research.

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Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Research Institute, Medstar Health Research Institute, Washington Hospital Center, 110 Irving Street NW, Room 1E12, Washington, 20010, DC, USA

    Allen J. Taylor

  2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

    Michiel L. Bots

  3. Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-159.2, 1105 AZ, Amsterdam, The Netherlands

    John J. P. Kastelein

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  1. Allen J. Taylor
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  2. Michiel L. Bots
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  3. John J. P. Kastelein
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Corresponding author

Correspondence to Allen J. Taylor.

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Competing interests

A. J. Taylor is a consultant for Abbott. M. L. Bots and J. J. P. Kastelein declare no competing interests.

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Taylor, A., Bots, M. & Kastelein, J. Meta-regression of CIMT trials—data in, garbage out. Nat Rev Cardiol 8, 128–130 (2011). https://doi.org/10.1038/nrcardio.2011.12

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