Caserta et al. investigated the effects of a cancer-associated mutation in PTEN (PTENFV). They generated PtenFV knock-in mice: the homozygous mice had intact AKT signalling and developed normally; the heterozyogus mice developed several types of carcinoma, none of which was usually associated with Pten deficiency. This mutation therefore exposes a new role for PTEN in tumour suppression that requires further investigation.
References
Caserta, E. et al. Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes Dev. 29, 1707–1720 (2015)
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Alderton, G. PTEN gains new powers. Nat Rev Cancer 15, 575 (2015). https://doi.org/10.1038/nrc4026
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DOI: https://doi.org/10.1038/nrc4026
