By separating genomics data from the predicted cellular source (such as stromal cell versus pancreatic tumour cell), Moffitt et al. have identified subtypes of pancreatic adenocarcinoma (PDAC). They characterized a basal-like subtype that has a worse prognosis than the subtype with activated stroma.
References
Moffitt, R. A. et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat. Genet. http://dx.doi.org/10.1038/ng.3398 (2015)
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Alderton, G. PDAC subtypes. Nat Rev Cancer 15, 575 (2015). https://doi.org/10.1038/nrc4025
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DOI: https://doi.org/10.1038/nrc4025
