Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts

Abstract

The majority of human solid tumours do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumour tissue can lead to metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and might better recapitulate human tumours than PDX models.

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Acknowledgements

This article is dedicated to the memory of A. R. Moossa.

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Correspondence to Robert M. Hoffman.

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The author is an unpaid affiliate of AntiCancer Inc. PDOX models are a research project of AntiCancer Inc.

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Hoffman, R. Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts. Nat Rev Cancer 15, 451–452 (2015). https://doi.org/10.1038/nrc3972

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