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Revisiting tissue specificity of germline cancer predisposing mutations

Abstract

Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?

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Acknowledgements

Work in the authors' laboratories was supported by the Giulio D'Angio Endowed Chair at the Children's Hospital of Philadelphia (JMM).

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Correspondence to John M. Maris.

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Maris, J., Knudson, A. Revisiting tissue specificity of germline cancer predisposing mutations. Nat Rev Cancer 15, 65–66 (2015). https://doi.org/10.1038/nrc3894

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