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Signalling

Uncovering new functions of PI3K mutations

Nature Reviews Cancer volume 14, pages 766–767 (2014)Cite this article

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in many cases the functional consequences of specific mutations are not known

Although cancer genomics studies are providing vast amounts of data on genes that are commonly mutated in cancer, in many cases the functional consequences of specific mutations are not known. Examination of the signalling pathways activated by the protein encoded by a common mutation in PIK3R1 (the p85α subunit of PI3K) allowed Cheung et al. to uncover that the mutant protein has neomorphic functions.

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References

  1. Cheung, L. W. T. et al. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. Cancer Cell 26, 479–494 (2014)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. Uncovering new functions of PI3K mutations. Nat Rev Cancer 14, 766–767 (2014). https://doi.org/10.1038/nrc3863

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