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Shouldn't we care about the biology of benign tumours?

Abstract

While focusing on malignant tumours seems medically reasonable, from a biological perspective, benign and malignant tumours provide complementary and perhaps equally relevant perspectives on the mechanisms of tumour invasion and metastasis. However, the biology of benign neoplasms is rarely studied.

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References

  1. Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell. 61, 759–767 (1990).

    Article  CAS  PubMed  Google Scholar 

  2. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell. 144, 646–674 (2011).

    Article  CAS  PubMed  Google Scholar 

  3. Mehine, M. et al. Characterization of uterine leiomyomas by whole-genome sequencing. N. Engl. J. Med. 369, 43–53 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Dankort, D. et al. BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nature Genet. 41, 544–552 (2009).

    Article  CAS  PubMed  Google Scholar 

  5. Bernards, R. & Weinberg, R. A. A progression puzzle. Nature. 418, 823 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Nguyen, D. X. & Massagué, J. Genetic determinants of cancer metastasis. Nature Rev. Genet. 8, 341–352 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. Sethi, N. & Kang, Y. Unravelling the complexity of metastasis — molecular understanding and targeted therapies. Nature Rev. Cancer. 11, 735–748 (2011).

    Article  CAS  Google Scholar 

  8. Wang, Y. et al. Dystrophin is a tumor suppressor in human cancers with myogenic programs. Nature Genet. 46, 601–606 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Vogelstein, B. et al. Cancer genome landscapes. Science. 339, 1546–1558 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Egeblad, M. et al. Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell. 18, 884–901 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Doyle, L. A. & Fletcher, C. D. Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am. J. Surg. Pathol. 37, 484–495 (2013).

    Article  PubMed  Google Scholar 

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Correspondence to Christopher D. M. Fletcher.

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Selected genes mutated in benign tumours of different lineages (PDF 97 kb)

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Marino-Enriquez, A., Fletcher, C. Shouldn't we care about the biology of benign tumours?. Nat Rev Cancer 14, 701–702 (2014). https://doi.org/10.1038/nrc3845

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