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Mining the genomes of exceptional responders

Nature Reviews Cancer volume 14, pages 291–292 (2014)Cite this article

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Abstract

The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?

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References

  1. Avicenna The Canon of Medicine (Persia, 1025).

  2. Willyard, C. 'Basket studies' will hold intricate data for cancer drug approvals. Nature Med. 19, 655–655 (2013).

    Article  CAS  Google Scholar 

  3. Stewart, D. J. & Kurzrock, R. Fool's gold, lost treasures, and the randomized clinical trial. BMC Cancer 13, 193 (2013).

    Article  Google Scholar 

  4. Chou, A. et al. Clinical and molecular characterization of HER2 amplified-pancreatic cancer. Genome Med. 5, 78 (2013).

    Article  Google Scholar 

  5. Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012).

    Article  CAS  Google Scholar 

  6. Chang, K. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nature Genet. 45, 1113–1120 (2013).

    Article  CAS  Google Scholar 

  7. Riley, W. T., Glasgow, R. E., Etheredge, L. & Abernethy, A. P. Rapid, responsive, relevant (R3) research: a call for a rapid learning health research enterprise. Clin. Transl. Med. 2, 10 (2013).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, Scotland, UK

    David K. Chang, Sean M. Grimmond, T. R. Jeffry Evans & Andrew V. Biankin

  2. Cancer Division, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 364 Victoria Street, Darlinghurst, Sydney, 2010, New South Wales, Australia

    David K. Chang & Andrew V. Biankin

  3. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, 2010, Australia

    David K. Chang & Andrew V. Biankin

  4. Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, 2200, New South Wales, Australia

    David K. Chang & Andrew V. Biankin

  5. South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, 2170, New South Wales, Australia

    David K. Chang & Andrew V. Biankin

  6. Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, 4067, Queensland, Australia

    Sean M. Grimmond

Authors
  1. David K. Chang
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  2. Sean M. Grimmond
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  3. T. R. Jeffry Evans
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  4. Andrew V. Biankin
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Corresponding author

Correspondence to Andrew V. Biankin.

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The authors declare no competing financial interests.

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Chang, D., Grimmond, S., Evans, T. et al. Mining the genomes of exceptional responders. Nat Rev Cancer 14, 291–292 (2014). https://doi.org/10.1038/nrc3723

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