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  • Opinion
  • Published:

The DREAM complex: master coordinator of cell cycle-dependent gene expression

Nature Reviews Cancer volume 13, pages 585–595 (2013)Cite this article

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A Corrigendum to this article was published on 23 August 2013

This article has been updated

Abstract

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.

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Figure 1: Differential cell cycle control by RB and the DREAM complex.
Figure 2: Common themes of repression connect the Muv genes and their homologues.
Figure 3: Tipping the balance from quiescence to proliferation in cancer.

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  • 23 August 2013

    On page 593 of this Opinion article, a citation to a key reference (Flowers. S., Beck, G. R. Jr & Moran, E. Tissue-specific gene targeting by the multiprotein mammalian DREAM complex. J. Biol. Chem. 286, 27867–27871 (2011)) was not included. This reference should have been cited at the end of the following sentence: "Perhaps isolation of the DREAM and the BMYB–MuvB complexes from distinct mammalian tissues will reveal functions in addition to cell cycle control130,131". This has now been corrected online.

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Acknowledgements

The authors gratefully acknowledge the many helpful discussions about DREAM with L. Litovchick, N. Dyson, M. Botchan and K. Engeland. This work was supported in part by US Public Health Service grants P01CA050661 and R01CA63113 to J.A.D.

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  1. Subhashini Sadasivam is at the Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India.,

    Subhashini Sadasivam

  2. James A. DeCaprio is at the Department of Medical Oncology, USA; the Department of Medicine, USA; and the Department of Medicine, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, Brigham and Women's Hospital, Boston, Massachusetts 02115, Harvard Medical School, Boston, Massachusetts 02115, USA.,

    James A. DeCaprio

  3. the Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA,

    James A. DeCaprio

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Sadasivam, S., DeCaprio, J. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer 13, 585–595 (2013). https://doi.org/10.1038/nrc3556

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