Velusamy et al. have identified a reciprocal chimeric fusion between the transcripts of yippee-like 5 (YPEL5) and the phosphatase PPP1CB in 97 of 103 (95%) chronic lymphocytic leukaemia (CLL) samples. No evidence was found for a genomic fusion between these loci, indicating a role for RNA-splicing events in forming the chimaeras. YPEL5–PPP1CB produced a PPP1CB protein with reduced activity, and PPP1CB silencing in a CLL cell line increased proliferation and colony formation. The chimaera was not seen in normal cells or in other cancers, so it may have a specific role in CLL pathogenesis.
ORIGINAL RESEARCH PAPER
Velusamy, T. et al. Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 4 Feb 2013 (doi:10.1073/pnas.1214326110)
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Seton-Rogers, S. Chimeric expression. Nat Rev Cancer 13, 149 (2013). https://doi.org/10.1038/nrc3481
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DOI: https://doi.org/10.1038/nrc3481
