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Metastasis

Dynamic interactions

Nature Reviews Cancer volume 12, pages 378–379 (2012)Cite this article

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A divergence in tumour-initiating and locally invasive programmes was confirmed by gene profiling

Two distinct clonal populations derived from PC-3 prostate cancer cells were shown to have either robust (PC-3/Mc cells) or poor (PC-3/S cells) metastatic ability following orthotopic, intravenous or intracardiac injection in NOD-SCID mice. PC-3/Mc cells also had a higher tumour-initiating potential, as shown by serial transplantation in immunocompromised mice. Despite the high metastatic ability of PC-3/Mc cells, they were less invasive in vitro than the non-metastatic PC-3/S cells. However, PC-3/Mc cells were more proliferative than PC-3/S cells and formed more non-adherent spheroids in culture and after serial plating. A divergence in tumour-initiating and locally invasive programmes was confirmed by gene profiling, which revealed that PC-3/Mc cells expressed higher levels of genes that are associated with an epithelial phenotype and self-renewal, whereas PC-3/S cells expressed mesenchymal markers and genes that are associated with promoting EMT. Similar results were observed using subpopulations derived from the T24 bladder cancer cell line, indicating that these observations are not unique to the PC-3 system.

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References

ORIGINAL RESEARCH PAPER

  1. Celià-Terrassa, T. et al. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Invest. 122, 1849–1868 (2012)Article

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FURTHER READING

  1. Brabletz, T. To differentiate or not — routes towards metastasis. Nature Rev. Cancer 11 May 2012 (doi:10.1038/nrc3265)

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Authors
  1. Sarah Seton-Rogers
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Seton-Rogers, S. Dynamic interactions. Nat Rev Cancer 12, 378–379 (2012). https://doi.org/10.1038/nrc3282

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