There have been major advances in our understanding of the cellular and molecular biology of the human malignancies that are collectively referred to as ovarian cancer. At a recent Helene Harris Memorial Trust meeting, an international group of researchers considered actions that should be taken to improve the outcome for women with ovarian cancer. Nine major recommendations are outlined in this Opinion article.
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The authors would like to thank the Ovarian Cancer Action, its Chair, A. Kaye, its staff and its many supporters, without whose drive and generosity the Helene Harris Memorial Trust meetings would not be possible. The authors also thank K. Swenerton, Cheryl Brown Outcomes Unit, British Columbia Cancer Agency, Canada, for providing some of the data in Figure 1 and for the concept of Figure 3. Further acknowledgements and sources of funding for some of the authors of this article can be found in the Supplementary information S1 (text) (see Further information).
R.C.B. receives royalties for CA125 from Fujirebio Diagnostics Inc. He serves on external advisory boards for Vermillion and Illumina. S.B.K. is a member of the Astra Zeneca advisory board. C.J.L. is a named inventor on patents regarding the use of PARP inhibitor and stands to financially gain under the ICR 'Rewards to Inventors' scheme. U.M. has received grants from the Medical Research Council, Cancer Research UK, the European Union, the Eve Appeal and the NIHR, UK. U.M. holds stock in Abcodia Ltd, has received travel funds from the American Society of Clinical Oncology and Abbott, and has research collaborations with Becton Dickinson.
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Vaughan, S., Coward, J., Bast, R. et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer 11, 719–725 (2011). https://doi.org/10.1038/nrc3144
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