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Of cancer and cave fish

Abstract

We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.

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References

  1. 1

    Wilkens, H. Convergent adaptations to cave life in the Rhamdia laticauda catfish group (Pimelodidai, Teleostei). Env. Bio. Fishes 62, 251–261 (2001).

    Article  Google Scholar 

  2. 2

    Humphreys, W. F. Milyeringa veritas (Eleotridae), a remarkably versatile cave fish from the arid tropics of northwestern Australia. Env. Biol. Fishes 62, 297–313 (2001).

    Article  Google Scholar 

  3. 3

    Li, Z., Gan, X. & He, S. Distinct evolutionary patterns between two duplicated color vision genes within cyprinid fishes. J. Mol. Evol. 69, 346–359 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Jeffery, W. R. Regressive evolution in Astyanax cavefish. Annu. Rev. Genet. 43, 25–47 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Niven, J. E. & Laughlin, S. B. Energy limitation as a selective pressure on the evolution of sensory systems. J. Exp. Biol. 211, 1792–1804 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Borowsky, R. Restoring sight in blind cavefish. Curr. Biol. 18, R23–R24 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Behrens, M., Wilkens, H. & Schmale, H. Cloning of the αA-crystallin genes of a blind cave form and the epigean form of Astyanax fasciatus: a comparative analysis of structure, expression and evolutionary conservation. Gene 216, 319–326 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Borowsky, R. & Wilkens, H. Mapping a cavefish genome: polygenic systems and regressive evolution. J. Hered. 93, 19–21 (2002).

    CAS  Article  Google Scholar 

  9. 9

    Gatenby, R. A., Gillies, R. J. & Brown, J. S. The evolutionary dynamics of cancer prevention. Nature Rev. Cancer 10, 526–527 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Rubin, H. Saturation density of skin fibroblasts as a quantitative screen for human cancer susceptibility. Cancer Epid. Bio. Prev. 18, 2366–2372 (2009).

    CAS  Article  Google Scholar 

  11. 11

    Mitchell, W. A. & Valone, T. J. The optimization research program: studying adaptations by their function. Q. Rev. Biol. 65, 43–52 (1990).

    Article  Google Scholar 

  12. 12

    Rosenberg, A. The supervenience of biologic concepts. Phil. Sci. 363–386 (1978).

  13. 13

    Rosenberg, A. The structure of Biological Science New York (Cambridge University Press, 1985).

    Google Scholar 

  14. 14

    Gatenby, R. A. & Gillies, R. J. A microenvironmental model of carcinogenesis. Nature Rev. Cancer 8, 56–61 (2008).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

Grant Support: 1U54CA143970-01

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Correspondence to Robert A. Gatenby.

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The authors declare no competing financial interests.

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Gatenby, R., Gillies, R. & Brown, J. Of cancer and cave fish. Nat Rev Cancer 11, 237–238 (2011). https://doi.org/10.1038/nrc3036

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