Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
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The authors are funded by Cancer Research UK grants C303/A7399 (J.J.B.) and C303/A5434 (P.J.G.).
J.J.B. is a named inventor on UK Patent GB2404441: “Assay methods relating to the action of geminin in the licensing of DNA replication complexes in transformed cells.”
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Blow, J., Gillespie, P. Replication licensing and cancer — a fatal entanglement?. Nat Rev Cancer 8, 799–806 (2008). https://doi.org/10.1038/nrc2500
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